Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B‐labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR‐loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR‐loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK
Layered double hydroxides (LDHs) are a class of materials with useful properties associated with their anion exchange abilities for a wide range of materials’ applications including adsorbent, catalyst and its support, ceramic precursor, and drug carrier. In order to satisfy the requirements for the detailed characterization and the practical application, the preparation of LDHs with varied composition and particle morphology has been examined extensively. The versatility of the preparation methods led LDHs with varied composition and micro/macroscopic morphology, which makes the application of LDHs more realistic. In the present review article, synthetic methods of LDHs are overviewed in order to highlight the present status of the LDHs for practical application.
Due to increasing interest in the development of advanced nanomaterials from nanosheets as building blocks, methods for the preparation of nanosheet materials and their hybrids have been studied carefully and extensively. In this review, studies of mechanochemical methods (solid-solid reactions under ambient conditions or solvent-free synthesis) for the preparation of intercalation compounds are summarized. Mechanochemical reactions without using solvent have operational advantages, such as their environmentally benign nature and the fact that separating and drying the products is not necessary. In addition to their advantages from green chemistry viewpoints, solid-state reactions have potential for the preparation of novel intercalation compounds which are not accessible by conventional solution-based methods.
A large quantity of MgAl-layered double hydroxide (LDH) nanoparticle was successfully obtained from a single batch from high concentration (as high as 1 M) of metal salts solution. LDH were obtained by the precipitation at room temperature under ambient pressure and subsequent aging. The phase purity, crystallinity, anion composition, and morphology (shape and size of the LDH crystals) were investigated to characterize the products. Chloride type MgAl LDH with well-defined platy shapes of the lateral size of 50 nm was obtained with the very high efficiency (approximately 10 g from the 160 mL of the starting solution).
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