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Abstract. Lean is a new open source theorem prover being developed at Microsoft Research and Carnegie Mellon University, with a small trusted kernel based on dependent type theory. It aims to bridge the gap between interactive and automated theorem proving, by situating automated tools and methods in a framework that supports user interaction and the construction of fully specified axiomatic proofs. Lean is an ongoing and long-term effort, but it already provides many useful components, integrated development environments, and a rich API which can be used to embed it into other systems. It is currently being used to formalize category theory, homotopy type theory, and abstract algebra. We describe the project goals, system architecture, and main features, and we discuss applications and continuing work.

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Recent clinical studies suggest that the efficacy of hormone therapy for prostate cancer depends on the characteristics of individual patients. In this paper, we develop a computational framework for identifying patient-specific androgen ablation therapy schedules for postponing the potential cancer relapse. We model the population dynamics of heterogeneous prostate cancer cells in response to androgen suppression as a nonlinear hybrid automaton. We estimate personalized kinetic parameters to characterize patients and employ δ-reachability analysis to predict patient-specific therapeutic strategies. The results show that our methods are promising and may lead to a prognostic tool for prostate cancer therapy.

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We present the framework of δ-complete analysis for bounded reachability problems of general hybrid systems. We perform bounded reachability checking through solving δ-decision problems over the reals. The techniques take into account of robustness properties of the systems under numerical perturbations. We prove that the verification problems become much more mathematically tractable in this new framework. Our implementation of the techniques, an open-source tool dReach, scales well on several highly nonlinear hybrid system models that arise in biomedical and robotics applications.

In this paper we describe a new tool, SReach, which solves probabilistic bounded reachability problems for two classes of stochastic hybrid systems. The first one is (nonlinear) hybrid automata with parametric uncertainty. The second one is probabilistic hybrid automata with additional randomness for both transition probabilities and variable resets. Standard approaches to reachability problems for linear hybrid systems require numerical solutions for large optimization problems, and become infeasible for systems involving both nonlinear dynamics over the reals and stochasticity. Our approach encodes stochastic information by using random variables, and combines the randomized sampling, a δ-complete decision procedure, and statistical tests. SReach utilizes the δ-complete decision procedure to solve reachability problems in a sound manner, i.e., it always decides correctly if, for a given assignment to all random variables, the system actually reaches the unsafe region. The statistical tests adapted guarantee arbitrary small error bounds between probabilities estimated by SReach and real ones. Compared to standard simulation-based methods, our approach supports non-deterministic branching, increases the coverage of simulation, and avoids the zero-crossing problem. We demonstrate our method's feasibility by applying SReach to three representative biological models and to additional benchmarks for nonlinear hybrid systems with multiple probabilistic system parameters.