Nationale:
Trichosporon
species are widely distributed in nature and are emerging opportunistic human pathogens.
Trichosporon
infections are associated with superficial cutaneous involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. Until now, there is no report in infective endocarditis by
Trichosporon mucoides
confirmed by molecular diagnostics
Patient concerns:
A 66-year-old man presented with a fever that had occurred for a period of 6 months. He had undergone aortic valve replacement 10 years prior. Transthoracic echocardiography showed vegetations on the prosthetic aortic valve and native mitral valve.
T mucoides
was detected in the cultures of blood and vegetations.
Diagnosis:
DNA sequencing using D/D2 region of rRNA and internal transcribed spacer were performed.
Interventions:
Infections were successfully controlled with valve replacement and voriconazole plus liposomal amphotericin B therapy.
Outcomes:
There has been no sign of recurrence for 18-months after treatment completion.
Lessons:
This is the first reported case of infective endocarditis due to
T mucoides
. Clinicians should consider
Trichosporon
species as causative agents of endocarditis in patients who have undergone cardiac surgery.
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