Background: Dyslipidemia is one of the important causes of cardiovascular disease related mortality and morbidity. Recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to find a suitable solution for reducing blood lipid in dyslipidemic patients by conducting a research on the effect of cinnamon in hypercholesterolemic rats.Objective: To study the lipid lowering effect of Cinnamomum cassia on experimentally induced hypercholesterolemic rats.Materials and Methods: This study was done on 30 male Long Evans rats weighing about 200--210 gram. For convenience, the study was divided into two experiments --- Experiment I and Experiment II. In experiment I, 12 animals were divided into two groups. One was Group A (n = 6, control group) fed on laboratory diet and the other was Group B (n = 6) fed on laboratory diet and cinnamon for 35 days. In experiment II, the remaining 18 rats were fed fatty mixture diet containing 1% cholesterol and 0.25% cholic acid. The hypercholesterolemic rats were then divided into 3 groups, Group C, D, and E (n=6 in each group). Group D and Group E were additionally fed on cinnamon powder and tablet atorvastatin for 35 days respectively. Serum TC, TG, LDL-C and HDL-C were measured after 35 days.Results: Fatty mixture diet increased TG, TC and LDL-C significantly. Cinnamon treated fatty mixture diet group showed that Cinnamomum cassia decreased plasma TC, TG and LDL-C. Atorvastatin therapy decreased TC, TG and LDL-C levels significantly compared with the lowering effect of cinnamon.Conclusion: The results of this experimental study indicate that Cinnamomum cassia can act as a hypocholesterolemic agent and thereby can improve cardiovascular functions
The chemical compositions of essential oil of Oscimum basilicum extracted by hydrodistillation and different solvent extractions were analyzed by GC-MS. Qualitative analysis of the essential oil as well as other extracts showed that majority of these are mono and sesquiterpenes. Most of the identified compounds are biologically important. Further the Oscimum basilicum leaf possesses certain characteristics that can be ascribed to cultivation on a domestic plantation.Keywords: Ocimum basilicum; Essential oil; Hydrodistillation; Different extracts; GC-MS.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i1.5409 J. Sci. Res. 3 (1), 197-206 (2011)
Dyslipidemia is highly prevalent in the urban and rural areas of Bangladesh but information in the suburban, is limited. The objective of this study was to determine the prevalence of dyslipidemia in sample population who live in the sub-urban area of Bangladesh. Random sampling of the volunteers aged > or = 18 years in Bhaluka upozilla of Mymensingh district was done. After 12-hour fasting, the blood sampling was drawn for the analysis of fasting glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. In the present study, we have shown that there is increasing trend of dyslipidemia even in the sub-urban community. Women had significantly higher body mass index, serum cholesterol and LDL cholesterol levels than men after 40 years of age. Of the study population 16.9% had high TC (e240 m/dl), and 8.8% had low HDL-C (d40 mg/dl). The population with high (e160 mg/dl) LDL-C was 15.7%. In addition, 17.8% had high TG (e200 mg/dl) and 2.0% had very high TG (e350 mg/dl). Our findings also suggest a protective role of ordinary Bangladeshi diet such as fish cooked in mustard oil on dyslipidemia. Individually, both fish and the mustard oil are rich in unsaturated fatty acids, and biologically, their beneficial effects are related not only to reduction of blood pressure, but also to lowering of lipids and to their antithrombotic effects. In conclusion, prevalence of dyslipidemia was very high in Bangladeshi sub-urban region. Useful role of fish cooked in mustard oil, as a protective factor needs to be probed further in future longitudinal studies. The observed prevalence of dyslipidemia in this study suggests the need for a comprehensive national policy to control dyslipidemia in Bangladesh. Further surveillance in this population is essential in verifying the impact of dyslipidemia as a risk of cardiovascular disease in Bangladeshi people. DOI: http://dx.doi.org/10.3329/uhj.v8i1.11662 University Heart Journal Vol. 8, No. 1, January 2012
Context: Diabetes mellitus is becoming a major burden upon healthcare facilities in all affected countries. Current therapies used for diabetics have side effects, so the current shift to the use of herbal preparations may be more effective, relatively low cost, less side effect and low toxicity.Objective: The present research was made to investigate the potential antidiabetic activity of Centella asiatica (L.) Urb. in alloxen induced diabetics. Materials and Methods:Rats were divided into 6 groups and C. asiatica was administered containing 50, 100 and 200 mg/kgbwt powder, respectively in 1ml water orally in group A, B and C rats. Metformin (150 mg/kgbwt) used as a reference standard drug. Blood glucose (BG), triglycerides (TG), total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) were estimated from the serum by using standard kits.Results: C. asiatica juice had shown significant lowered the blood glucose levels in all groups. In addition, body weight, organ (liver, kidney, heart and pancreas) weight, food intake, water intake were also examined in all treated groups and compared against diabetic control group. After 22 days daily administration of C. asiatica, diabetic treated rats showed improvement in body weight, water intake as compared to diabetic control rats. In alloxan induced diabetic rats the maximum reduction in BG, TG, TC, HDL, LDL, SGOT and SGPT were observed at a dose level of 50 mg/kgbwt. Conclusion:The present data indicates that C. asiatica juice possesses potential as an antidiabetic action
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