Biocompatible lipo-histidine hybrid materials conjugated with IR820 dye show pH-sensitivity, efficient intracellular delivery of doxorubicin (Dox), and intrinsic targetability to cancer cells. These new materials form highly uniform Dox-loaded nanosized vesicles via a self-assembly process showing good stability under physiological conditions. The Dox-loaded micelles are effective for suppressing MCF-7 tumors, as demonstrated in vitro and in vivo. The combined mechanisms of the EPR effect, active internalization, endosomal-triggered release, and drug escape from endosomes, and a long blood circulation time, clearly prove that the IR820 lipopeptide DDS is a safe theranostic agent for imaging-guided cancer therapy.
In this study, we proposed the sacrificial anode cathodic protection method as a countermeasure to reduce the corrosion of the steel sculptures under outdoor conditions and proved the anticorrosive effect experimentally. To affix the Mg sacrificial anode and the steel plate specimen, an adhesive bonding strength test was conducted with three types of conductive adhesives. Hence, the suitability of the conductive epoxy adhesive was confirmed, and a C-clamp experiment was conducted to supplement the connection. In addition, by applying a sacrificial anode suitable for the soil where the artwork is installed, the field applicability was reviewed through an artificial determination of resistance to cyclic corrosion conditions test(salt fog/dry/humid) to prove the suitability of the cathodic protection method by sacrificial anode. Hence, corrosion monitoring is in progress by test-laying steel plate specimens in an outdoor sculpture park to identify natural deterioration. In the future, based on the results of the outdoor exposure test, we plan to determine the proper method of bonding the sacrificial anode and the steel sculpture, and the replacement period of the sacrificial anode.
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