Hyperbranched polyglycidol/phosphatidylcholine and phosphatidylethanolamine hybrid liposomes for the pH-sensitive delivery of doxorubicin

Kinetic and Mechanistic Study of Heterogeneous Double Metal Cyanide-Catalyzed Ring-Opening Multibranching Polymerization of Glycidol

“…The conversion of glycidol was proceeded to near completion within 2−10 h, depending on the reaction conditions. The monomer consumption according to time was monitored using 1 The relationship between the monomer consumption and the polymerization time at four different polymerization temperatures is shown in Figure 4a. The first-order time− conversion plots indicated that the polymerization proceeded without an induction period and followed pseudo-first-order kinetics with respect to the monomer concentration, which in turn suggested that the reaction proceeded via a relatively simple mechanism.…”

“…A hyper-branched polyglycidol (HBPG) with a high degree of branching (DB) has attracted increasing attention from both academia and industry because of its biocompatibility, versatility, hydrophilicity, and high number of available functional groups, and its feasibility to use as alternatives to dendrimers and star polymers for various applications including drug delivery systems. − The semi-branched polyglycidol (SBPG) with a low DB is also attractive as a hydrogel substrate and a coating biomaterials because of the enhanced thermal stability, ability to form hydrogen bonds, and possibility to derivatize their primary alcohol. − Extensive studies have been undertaken to control the macromolecular structure of the resultant polyols . The ring-opening multibranching polymerization (ROMBP) of latent cyclic AB 2 -type monomers is a key reaction to achieve a wide variety of polyglycidols as well as complex macromolecular architectures. − …”