A series of novel fluorinated 1,5-benzothiazepine derivatives were
synthesized, characterized and evaluated for in vitro anticancer and
antibacterial activity. The in vitro anticancer activity of the synthesized
compounds 4(a-h) was evaluated against four human cancer cell lines namely
lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3) cancer.
Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50 <10 ?g ml-1
against all four human cancer cell lines which was comparable to standard
drug Adriamycin. Additionally, antibacterial activity of synthesized
compounds was estimated using resazurin microtiter assay (REMA) and compared
with standard drug Ampicillin. Among the synthesized compounds, 4c, 4d, 4g
and 4h showed in good antibacterial activity and all the synthesized
compounds were found to be more active towards gram negative than gram
positive. These promising results obtained from in vitro anticancer and
antibacterial activity, inferred that the synthesized compounds are capable
of being anticancer as well as antibacterial agent.
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