Background:
Biscoumarin scaffolds are known for their promising pharmacological properties.
These compounds have not been studied for their activity against tuberculosis strains.
Objective:
Unveil the antitubercular properties of biscoumarin scaffolds.
Methods:
Biscoumarin derivatives (3a-3l) were synthesized using lemon juice as a catalyst and were investigated for their in-vitro anti-tubercular activity against H37Rv strain of Mycobacterium tuberculosis using Microplate Alamar Blue Assay Method (MABA). Their binding interaction was investigated by Molecular Docking
Studies using InhA with PDB-ID: 2NSD as target receptors in H37Rv strain of Mycobacterium tuberculosis.
These derivatives (3a-3l) were subjected to neutrophil function test.
Results:
The results revealed that compounds 3b, 3c, 3d, 3f, 3i, 3j showed excellent activity with MIC 1.6
µg/mL. Molecular docking interactions for their antitubercular activity proved that the derivatives (3a-3l) can
easily bind into the pockets of InhA enzyme. Neutrophil function test signified that they exhibit moderate neutrophil functions assuring that they do not harm the functioning of Neutrophils.
Conclusion:
These studies have awakened the property of Biscoumarins as promising anti-tubercular scaffolds.
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