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This work introduces a new population-based stochastic search technique, named multi-variant differential evolution (MVDE) algorithm for solving fifteen well-known real world problems from UCI repository and compared to four popular optimization methods. The MVDE proposes a new self-adaptive scaling factor based on cosine and logistic distributions as an almost factor-free optimization technique. For more updated chances, this factor is binary-mapped by incorporating an adaptive crossover operator. During the evolution, both greedy and less-greedy variants are managed by adjusting and incorporating the binary scaling factor and elite identification mechanism into a new multi-mutation crossover process through a number of sequentially evolutionary phases. Feature selection decreases the number of features by eliminating irrelevant or misleading, noisy and redundant data which can accelerate the process of classification. In this paper, a new feature selection algorithm based on the MVDE method and artificial neural network is presented which enabled MVDE to get a combination features’ set, accelerate the accuracy of the classification, and optimize both the structure and weights of Artificial Neural Network (ANN) simultaneously. The experimental results show the encouraging behavior of the proposed algorithm in terms of the classification accuracies and optimal number of feature selection.