IntroductionSexual and Reproductive Health access to Information services is still a pressing need for youth in Uganda even during the COVID-19 pandemic, which has disrupted health care access in many countries. The aim of this study was to explore the challenges in access and utilization of sexual and reproductive health services as faced by youth during the COVID-19 pandemic lockdown in Uganda.MethodsThis was a cross-sectional study carried out from 28th April 2020 to 11th May 2020 in Uganda. An online questionnaire was disseminated to youth aged between 18 and 30 years over a period of 14 days. The snowball sampling method was used to recruit participants. STATA version 14.2 was used for statistical analysis.ResultsOf 724 participants, 203 (28%) reported that they did not have access to information and/or education concerning sexual and reproductive health (SRH). More than a quarter of the participants (26.9%, n = 195) reported that testing and treatment services of sexually transmitted infections were not available during the lockdown, and 27.2% could not obtain contraceptive supplies. Access to HIV/AIDS care services and menstrual supplies was also impaired. Lack of transportation was the commonest factor cited as limiting access to SRH services during the lockdown (68.7%), followed by the long distance from home to SRH facilities (55.2%), high cost of services (42.2%) and the curfew (39.1%). Sexually transmitted infections were the commonest SRH problems related to SRH during the lockdown (40.4%) followed by unwanted pregnancy (32.4%) and sexual abuse (32.4%). Marital, educational, and employment status were significantly correlated with the reported experiences of the participants.ConclusionAccess to SRH information and services for Ugandan youth was restricted during the COVID-19 lockdown and leaving them vulnerable to various SRH risks and adverse outcomes. Lack of transportation, long distances to health facilities, and high cost of services were important limiting factors. The Government and other stakeholders should incorporate SRH among the priority services to be preserved during future outbreaks.

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Breastfeeding has proven to be a reference standard for infants' and young children nutrition worldwide.Improvement of breastfeeding rates is important if lives of under-five age children are to be saved yearly. In Uganda, malnutrition remains a serious health problem contributing significantly to both infant and child mortality and this has been attributed to low levels of breast feeding practices. The objective of this study was to assess the influence of knowledge and occupation of mothers on breastfeeding practices of infants and young children in Bushenyi, Uganda. A heath facility-based cross-sectional study was conducted among lactating mothers who attended Kyabugimbi health center IV, Ishaka Adventist Hospital and Kampala International University-Teaching Hospital (KIU-TH). Data was collected using a self-administered structured questionnaire from 346 participants. Majority (87.6%) of the participants had knowledge of the right time to initiate breast milk, majority (87.3%) and (93.9%) had good knowledge of exclusive breastfeeding and complementary feeding duration respectively. Majority (87.6%) of the mothers initiated breast milk within 1 hour of child birth. Only 31.9% of children above 6 months were exclusively breastfed. Majority (81.9%) of the mothers practiced complementary breastfeeding for at least 2 years. House wives have 42% [OR: 1.42, 95% (1.31-3.88) x 2 =0.79] higher odds to practice breastfeeding while mothers whose occupation is studentship have 2 times [OR: 2.04, 95% (1.31-3.88) x 2 =1.767] higher odds to practice breastfeeding optimally. Young children in Bushenyi district are at risk of malnutrition and childhood diseases as breastfeeding practices especially exclusive breastfeeding do not meet the national and WHO target and recommendation given that only three in ten children were exclusively breastfed. A combination of rural health outreaches and health education could be a possible option for the improvement of breastfeeding practices in the region.

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Aim: This study evaluated the effect of ethanol leaf extract of Catha edulis on the prefrontal cortex oxidative markers and hematological profile of Wistar rats. Study Design: The study design was experimental. Place and Duration of Study: Department of Biochemistry, Kampala International University, Uganda and Faculty of Medicine, Department of Pharmacy, Mbarara University of Science and Technology, Mbarara, Uganda. Between January and May, 2021. Methodology: Fresh C. edulis leaves were collected after on-spot identification, and authenticated before being chopped into small pieces and pulverized mechanically. The powdered material was extracted through cold maceration using 70% ethanol for 72 h. The extract was concentrated in vacuo to dryness at 40oC using rotary evaporator. The lethal dose (LD50) of the crude extract was determined using acute toxicity test. The sub-acute toxicity of the crude extract was evaluated by orally administering daily doses of 250, 500, and 1000 mg/kg to the male Wistar rats for 28 days. The animals were monitored for mortality, behavioral and physiological signs of toxicity. Superoxide dismutase (SOD), Catalase (CAT) activities and Malondialdehyde (MDA) levels were estimated using standard methods. The blood samples were analyzed using the automated hematology analyzer: Mindray BC-6000. Shenzhen, China. Results: The median lethal dose (LD50) of the C. edulis leaf extract was greater than 5000mg/kg b w. The SOD and CAT activities of C. edulis treated groups compared to the control group were significantly (p < 0.05) reduced, the malondialdehyde (MDA) levels were increased in C. edulis treated groups compared to the control group. There was no significant change in the hematological parameters, however, there were slight variations in the WBC and RBC counts in some C. edulis treated groups. Conclusion: Long term chewing of C. edulis could result in oxidative stress. It is therefore important for chronic C. edulis leaf chewers to take caution.