Cancer is one of the leading causes of death worldwide. In the available treatments, chemotherapy is one of the most used, but has several associated problems, namely the high toxicity to normal cells and the resistance acquired by cancer cells to the therapeutic agents. The scientific community has been battling against this disease, developing new strategies and new potential chemotherapeutic agents. However, new drugs often exhibit poor solubility in water, which led researchers to develop functionalized nanosystems to carry and, specifically deliver, the drugs to cancer cells, targeting overexpressed receptors, proteins, and organelles. Thus, this review is focused on the recent developments of functionalized nanosystems used to carry poorly water-soluble drugs, with special emphasis on liposomes and albumin-based nanosystems, two major classes of organic nanocarriers with formulations already approved by the U.S. Food and Drug Administration (FDA) for cancer therapeutics.

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Introduction The Sexually Transmitted Infections (STIs) are a Public Health problem concern Worldwide. They not only have a direct, but also an indirect impact on sexual Health in afflicted person's life, as they facilitate the sexual transmission of Human Immunodeficiency Virus (HIV). In 2016, the World Health Organization (WHO) estimated 6,3 million new Syphilis infections out of 376 million STIs (95% CI: 5,5-7,1 million). The worldwide prevalence of Syphilis is 0,5% (95% IC: 0,4-0,6). WHO is also concerned about Brazilian syphilis rates infection, since its sexual transmission increased from 59,1 cases in 2017, to 75,8 cases out of 100.000 persons, in 2018. Objectives Demographic analysis, incidence and prevalence rates of syphilis among recently HIV diagnosed Adults in a Center of São Paulo, Brazil Patients and Methods A Cohort Study in a population of 576 persons recently HIV diagnosed from September/2013 to July/2019. The rates were obtained by performing a nontreponemal test: Venereal Disease Research Laboratory (VDRL) Results Epidemiological analysis from 576 persons: 53,3% were Caucasian, 80% were Men who have sex with Men (MSM), 49% had more them 3 occasional partners, the average age was 30 y.o. and the median age was 28 y.o.18 - 65). Prevalence of Syphilis: 16,3%. Incidence rate: 9,6 persons/year. Conclusions considering that the STIs including syphilis, facilitate HIV transmission and also other STIs, we need to perform a stricter ISTs surveillance in the sexually active population, mainly in MSM to reduce all the STIs including HIV. Key messages Demographic analysis, incidence and prevalence rates of syphilis among recently HIV diagnosed Adults in a Center of São Paulo, Brazil. The Sexually Transmitted Infections (STIs) are a Public Health problem concern Worldwide.

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