Cassava (Manihot esculenta Crantz), a widely used common vegetable of Indian origin contains dietary goitrogens. Goitrogenic content, in vitro anti-thyroidal activity and in vivo antithyroid potential of fresh and cooked cassava of Indian origin in albino rats with and without iodine supplementation were evaluated in this study. In vitro inhibition of thyroid peroxidase (TPO )activity was found with fresh and cooked cassava extract but the presence of extra iodide in the incubation media had shown reduction in such inhibition to an extent. Inhibition constant (IC 50 ) and PTU equivalence of fresh cassava were 42.5 ± 1.35µg and 2.21 respectively. After consumption, cyanogenic constituents in cassava are metabolized to thiocyanate and iodine-retaining capacity seems to be dependent on thiocyanate exposure. In cassava fed rats, the urinary iodine concentration resembled the state of adequate iodine nutriture but thyroid gland fails to utilize available iodine. Increased thyroid weight (P < 0.001), inhibited thyroid peroxidase (TPO) activity and reduced thyroid hormone profiles (P < 0.001) were noted in fresh and cooked cassava fed rats, resembling a relative state of morphological as well as biochemical hypothyroidism even in presence of adequate iodine.
This article is a study on iodine nutritional status among 1627 school children aged 6-12 years, along with biochemical analysis of iodine of 200 urine samples, 50 drinking water samples and 175 salt samples carried out in certain randomly selected areas of the district Howrah in Gangetic West Bengal. Results indicate that the entire region is clinically goitre endemic having goitre prevalence 38%; however the median urinary iodine level was 25 microg/dl indicating no biochemical iodine deficiency, 70% salt samples had a recommended level of iodine and the region was found to be environmentally iodine sufficient. Consumption of dietary goitrogen and hard drinking water may have the possible role for the persistence of endemic goitre in the region.
Iodine content in drinking water samples ranged from 1.8-2.6 microg/l showing that the studied region is environmentally iodine deficient. Inspite of the consumption of adequate iodine, the existing goiter prevalence among school children during post salt iodization phase ensures that environmental factors other than iodine deficiency may have the possible role in the persistence of endemic goiter in the population. The role of thiocyanate in this regard may not be ruled out.
Cleistothecia in Pseudallescheria boydiiAcid Fast filamentous Nocardia spp. in Kinyoun stain Conclusion: Suppurative keratitis is one of the leading causes of blindness in rural India and most often occurs due to superficial corneal trauma, accounting for 84.84% of culture positive cases. In patients of corneal trauma with vegetative matter which was the most common traumatic agent,78.57% developed fungal keratitis whereas 36.84% developed bacterial keratitis (total of 64.28%). Aspergillus spp was responsible for most of the fungal infections and Staphylococcus aureus accounted for the majority of bacterial infections. It is imperative to know the local etiology of keratitis in a particular region particularly if diagnosis is going to be reliant on clinical signs for the prompt treatment of suppurative keratitis. This study helps in finding the most prevalent microorganisms in this region.
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