On the row of various cancers in the world, the Lung cancer falls to number two in both female and male. Various surgical and non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, and radiotherapy are employed in the treatment of lung cancer. However, most of these techniques are costly, complex and lacks patient compliance. In case of chemotherapy, it is associated with lack of specific tumour targeting, with limited drug solubility leads insufficient amount of drug reaches to a tumor site. To overcome these demerits associated with chemotherapy, various types of nanoparticles (both organic and inorganic) are synthesized and studied in treating lung cancers. In this article, we have reviewed the various types of nanoparticles that have been used in treating lung cancers. This review was carried out by searches of relevant published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles. The following search terms were used: Lung cancer, Target delivery, animal models, Nanoformulation, Nanoparticles and Polymeric Nanoparticles.

Over the last few years, there is tremendous growth of melanoma skin cancer in all around the world. Paclitaxel is an antineoplastic drug which is widely used for breast cancer, lung cancer, and Kaposi sarcoma. It is available only in the form of intravenous (IV), which produces tissue damage and hypersensitivity in some patients if the dose is over. In the present article, the new initiative formulation is done for melanoma skin cancer with transfersomes drug delivery systems. A different formulation of transfersomes is prepared using Span. The various characterization is done for the transfersomes like morphology, entrapment efficacy, in vitro drug release dialysis bag method. By using the Carbopol 940, the transfersomes gel was prepared. Paclitaxel-loaded transfersomes (FS-2) shows the positive entrapment efficacy 68.2% and the vesicle size 200 nm. From the in vitro dialysis bag method, FS-2 showed the high rate of drug release by nearly 72% in 12 hrs. we conclude that this will be the initial step for the further studies of melanoma skin cancer and provide the better treatment for skin cancer.

Skin cancer is one of the leading causes of cancer-related deaths worldwide. It is estimated that by 2030, there will be around 13.1million deaths can occur due to skin cancer. Current treatment of skin cancer includes surgery, radiation and chemotherapy. Chemo-resistance, off-target effects and poor bioavailability are the major challenges for currently available drugs for the treatment of skin cancer. Transfersomes is a novel, elastic vesicular drug carrier composed of phospholipids, surfactants and ethanol for enhanced transdermal delivery. This article we have reviewed about merits/demerits, liposomes vs transfersomes, preparation methods, characterization, mechanism of skin delivery, and application and regulatory aspects of transfersomes in treating various skin cancers.