Nanoparticles for the Treatment of Lung Cancers

Abstract

On the row of various cancers in the world, the Lung cancer falls to number two in both female and male. Various surgical and non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, and radiotherapy are employed in the treatment of lung cancer. However, most of these techniques are costly, complex and lacks patient compliance. In case of chemotherapy, it is associated with lack of specific tumour targeting, with limited drug solubility leads insufficient amount of drug reaches to a tumor site. To overcome these demerits associated with chemotherapy, various types of nanoparticles (both organic and inorganic) are synthesized and studied in treating lung cancers. In this article, we have reviewed the various types of nanoparticles that have been used in treating lung cancers. This review was carried out by searches of relevant published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles. The following search terms were used: Lung cancer, Target delivery, animal models, Nanoformulation, Nanoparticles and Polymeric Nanoparticles.

Cisplatin-Loaded Polybutylcyanoacrylate Nanoparticles with Improved Properties as an Anticancer Agent

“…The application of current chemotherapy is limited due to the lack of target specificity, recurrence, and superficial increase in longevity of patients. Moreover, oral and intravenous (IV) administrations of anti-cancer drugs cause various issues, such as drug molecule degradation in the stomach pH, drug molecule alterations during the process of liver metabolism, and the lack of specificity in the conventional treatment methods, which cause toxicity and side effects [18].…”

Recent Progress in the Theranostics Application of Nanomedicine in Lung Cancer

“…Due to high biocompatibility, better stability and biodegradability current researchers have shifted their focal point of research towards using the bio-nanoparticles including protein nanoparticles, solid lipid nanoparticles, viral nanoparticles, aptamers, and apoferritin, wherein a bio-mimicking component is incorporated to the therapeutic nanoparticles [59,60]. In the recent past, these types of nanoparticles were successfully designed, synthesized, and utilized for cancer theranostics applications in lung cancer [59,61,62].…”

Identification of potential descriptors of water-soluble fullerene derivatives responsible for antitumor effects on lung cancer cells via QSAR analysis

“…The nanoparticle drug delivery systems [19] have potential effects that can be applied to improve the antitumor treatment [20] , [21] , [22] , [23] . For instance, the nanoparticle-based platform can serve as a highly efficient way of delivering drugs for lung cancer therapy [24] , [25] , [26] .…”