Synthesis of bis(indolyl)methane/dihydropyrimidinone based bis‐amide‐triazole hybrid compounds has been achieved via one‐pot six/seven‐component sequential Ugi‐Click reaction. Two molecular libraries of anti‐bacterial compounds containing significant pharmacophoric nuclei were synthesized in good yield and purity using green solvent, mild reaction conditions with atom economy by structural modifications in three independent starting materials.
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