Objectives: To determine age-specific prevalence of than females in the young age group, however, the prevalence rates are comparable in the older age hypertension and blood pressure (BP) levels in relation to diet and lifestyle factors in North Indians.groups

Alzheimer's disease (AD) could result from a multifactorial process involving both genetic predisposition and exposure to environmental factors like pesticides. A case control study of 70 patients of AD and 75 controls was done to examine the association between organochlorine pesticides (OCPs) and risk of AD. OCPs (hexachlorocyclohexane (HCH), aldrin, dieldrin, endosulfan, pp'-dichlorodiphenyldichloroethylene (pp'-DDE), op'-DDE, pp'-dichlorodiphenyltrichloroethane (pp'-DDT), op'-DDT, pp'-dichlorodiphenyldichloroethane (pp'-DDD) and op'-DDD) were extracted from blood and quantitatively estimated using gas chromatography. A Mann-Whitney U test revealed significant difference in β-HCH levels (U = 1237.00, W = 4087.00, z = -6.296, p = 0.000, r = -0.71), dieldrin levels (U = 1449.00, W = 4299.00, z = -5.809, p = 0.000, r = -0.68) and pp'-DDE levels (U = 2062.00, W = 4912.00, z = -2.698, p = 0.007, r = -0.59) between AD patients and controls. In conclusion, this study supports epidemiological studies that associate exposure to pesticides with increased risk of AD, and we identified the specific pesticides β-HCH, dieldrin and pp'-DDE that are associated with the risk of AD in the north Indian population. However, further research is needed to establish the potential role of these OCPs as an etiologic agent for AD case.

Rice is a staple food for more than 60% of world population and it's the world's most consumed cereal. The rice grains contain many bioactive components as one of the major content which are the group of substances with beneficial health properties that are produced as secondary metabolites during grain filling. In rice flavonoids include tricin, luteolin, apigenin, quercetin, isorhamnetin, kaempferol and myricetin have human health benefits. This compound possesses many properties such as antioxidant, anticancer, antiinflammation, cholesterol lowering activity and also illustrates prevention of human diseases like cancer and cardiovascular diseases. Bioactive compounds and flavonoids show different mode of actions includes, direct radical scavenging activity, cell membrane interaction, interacting with the protein of signaling pathways, inhibition of cell proliferation, platelet aggregation, cholesterol oxidation, natural killer cell and macrophage activation and inhibition of angiogenesis.

Background: Sparse published data are available regarding clinical presentation and complications of falciparum malaria from Andhra Pradesh state. Methods: In this prospective, observational study conducted during the period November 2012 to June 2014 at our teaching hospital in Kuppam, Andhra Pradesh, adult patients (n=96) admitted with fever confirmed to be suffering from falciparum malaria based on peripheral blood smear examination and / or malaria antigen test positive by rapid diagnostic test were studied. The clinical presentation and various complications of falciparum malaria were documented. Results: The male to female ratio was 2:1. Majority of the patients (70%) were in the age group 26-60 years. Fever was present in all cases. Splenomegaly (66%) was the most common physical sign followed by pallor (31%) and icterus (22%). Anaemia (51%), was the most common complication, followed by cerebral malaria (33.3%), acute respiratory distress syndrome (ARDS) (32.3%), acute kidney injury (AKI) (29.2%), and jaundice (25%). Majority of the patients presented with multiple complications (73%) than single complication (27%). Artemesinin-based combination therapy was administered to 72 of the 96 patients of whom 43 patients recovered. Quinine therapy was given to 14 patients of whom 10 recovered. Quinine plus ACT combination therapy was given to 10 patients and 7 recovered. seven of the 96 patients died; and 29 out of 96 patients were taken home against medical advice. Overall 36/96 (37.5%) patients had a poor outcome. All 7 patients who expired had multiple complications. Mortality was higher in patients who had co-existent AKI, hypotension and cerebral malaria. Conclusion: Early identification of high risk cases and institution of prompt treatment can reduce the mortality rate in falciparum malaria.

A like others, livestock industries are badly affected during lockdown periods due to COVID-19 pandemic. The COVID-19 disease outbreak was originated in Wuhan city of Hubei province of China during the month of December 2019. On the basis of whole virus genome sequence analysis and other phylogenetic characteristics, International Committee on Taxonomy of Viruses (ICTV) group classified that COVID-19 is a caused by Severe Acute Respiratory Syndrome coronavirus-2 (SARS Cov2). Its genome sequence homology analysis also revealed that the nucleotides sequence of human corona virus (SARS Cov-2 virus) is 87.5% - 96.3% similar to corona viruses of bat’s origin. During lockdowns, it is relatively easy to close down the factories, IT parks, hotels, Shopping malls and multiplexes but it is not so easy with agriculture and animal husbandry; these sectors will continue to produce.

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