Purpose: The aim of his study was to determine serum oxidant status (TOS), antioxidant status (TAS), and paraoxonase (PON1) levels and to determine their diagnostic values in patients diagnosed with COVID-19. Materials and Methods: The research was carried out on patients diagnosed with COVID-19. Within the scope of the study, a total of 87 patients with a diagnosis of COVID-19, 48 (55.1%) male and 39 (44.9%) were evaluated. Total antioxidant determination was performed using a microplate reader according to the Erel method. To calculate the Oxidative stress index (OSI), TOS and TAS levels were determined. Results: Male gender was associated with high PON1, smoking with high TOS, the presence of hypertension and Diabetes mellitus (DM) diseases with low OSI, and the presence of asthma with low PON1. High PON1 was found to be associated with shorter hospitalization duration and high TOS was associated with longer hospitalization duration. TAS and TOS levels increased significantly due to the increase in CRP, TOS levels due to the increase in neutrophil level, OSI levels due to the increase in leukocyte level, PON1 levels increased due to the increase in LDH level TAS, TOS, OSI, and PON1 cut-off values were 1.41 (AUC: 0.647), 4.56 (AUC: 0.493), 0.421 (AUC: 0.505) and 340 (AUC: 0.536), sensitivity values were 65.5, 55.2, 48.3 and 51.7; specificity values were calculated respectively as 62.1, 46.6, 34.5 and 53.4. Conclusion: Although it is seen that oxidative stress types have diagnostic value, there is a need for more comprehensive studies with larger samples on the subject.
Warfarin-induced skin necrosis is a rare complication of warfarin therapy and is associated with high mortality. Here, we present a case of warfarin-induced skin necrosis, that was fatal in a 53-year-old female patient who was started on warfarin treatment 5.5 years ago due to atrial fibrillation and previous mitral valve surgery. Patients using warfarin should be evaluated for warfarin-induced skin necrosis when they present with skin lesions. Early diagnosis, early discontinuation of the drug, early initiation of supportive treatment can be life-saving.
Aim: COVID-19 progresses rapidly and severely and often causes death in people with underlying health problems or co-morbidities. This study aimed to investigate the effect of clinical and some specific laboratory parameters on the prognosis and mortality of critically ill COVID-19 patients who need to be followed in the intensive care unit (ICU). Subjects and methods: This is a retrospective cohort study. A total of 180 patients treated in the ICU were included in the study. The data of clinical and levels of D-dimer, cardiac troponin I (cTnI), Ferritin, and CK-MB were researched. The multivariate and univariate logistic regression models were employed to investigate the risk factors affiliated with in-hospital death. Results: There was a significant difference in mortality between women and men (p=0.002). Hypertension was the most common comorbid disease, mortality was detected to be significantly greater in patients over 65 years of age. The serum D-dimer, cTnI, CK-MB, and ferritin levels were found to be higher in patients at risk. In the multivariate logistic regression model, we detected that ferritin above 300 μg/l (p=0.05) alongside cancer was associated with mortality. Conclusions: This study showed that advanced age is an important risk factor as well as the mortality of patients with cancer –especially those with a ferritin value above 300 μg/l and patients with a high cTnI value. Mortality was significantly higher in patients with increased serum D-dimer, cTnI, CK-MB, and ferritin levels.
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