The skin's main function is to act as a physical barrier against harmful substances. Medical adhesive-related skin injury (MARSI) is a prevalent and under-reported condition that compromises the skin's integrity. Repeated applications and removal of appliances can increase the likelihood of MARSI occurring. Prevention and treatment are key to ensure appropriate skin preparation, product appliance and removal. The use of structured approaches is imperative and there is a need to increase the awareness of MARSI among patients and health professionals to ensure that informed decisions are made.