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Background: Thyroid hormone receptor (TR) sumoylation is essential for thyroid hormone regulation of gene expression. Results: TR sumoylation mutants impair differentiation though down-regulation of C/EBPs, constitutive interaction with NCoR, interference with PPAR␥ signaling, and disruption of the Wnt canonical signaling pathway important for preadipocyte proliferation. Conclusion: TR sumoylation site mutations impair preadipocyte proliferation and differentiation. Significance: TR sumoylation is required for adipogenesis.

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Coccidioides immitis (and C. posadasii) are endemic fungi of the southwestern United States and northern Mexico. Uncomplicated, symptomatic Coccidioides infection most commonly causes a self-limited pneumonia; however, immunocompromised patients can manifest severe pneumonia with an additional risk of dissemination to bone, joints, soft tissues, and in the most severe the cases, the central nervous system. In the year 2020 clinicians are challenged with a previously unseen volume of acute respiratory complaints as a result of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. We present a patient with respiratory failure secondary to SARS-CoV-2 who experienced prolonged hypoxia and neurologic deterioration, eventually leading to a diagnosis of occult disseminated coccidiomycosis involving meningitis, miliary-pattern pneumonia, and cutaneous lesions.

Leishmaniasis is a parasitic infection classified into Old World and New World species of sandfly vectors, classically Phlebotomus and Lutzomyia, respectively. 1 Old World leishmaniasis, seen in the Eastern hemisphere, typically manifests as cutaneous and visceral disease. New World leishmaniasis, arising in Latin and South America, results in cutaneous, mucocutaneous, and visceral disease. The incidence of