The Empatica E3 is a wearable wireless multisensor device for real-time computerized biofeedback and data acquisition. The E3 has four embedded sensors: photoplethysmograph (PPG), electrodermal activity (EDA), 3-axis accelerometer, and temperature. It is small, light and comfortable and it is suitable for almost all real-life applications. The E3 operates both in streaming mode for real-time data processing using a Bluetooth low energy interface and in recording mode using its internal flash memory. With E3, it is possible to conduct research outside of the lab by acquiring continuous data for ambulatory situations in a comfortable and non-distracting way.

Running title: Wearable multimodal motor seizure detectors Onorati et al. 2 Summary Objective:New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive, automated and provide false alarm rates bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors. Methods:Hand-annotated video-electroencephalography seizure events were collected from 69 patients at 6 clinical sites. Three different wristbands were used to record electrodermal activity (EDA) and accelerometer (ACM) signals, obtaining 5,928 hours of data, including 55 convulsive epileptic seizures (6 focal tonic-clonic seizures and 49 focal-to-bilateral-tonicclonic seizures) from 22 patients. Recordings were analyzed off-line to train and test two new machine learning classifiers and a published EDA and ACM-based classifier. Moreover, wristband data were analyzed to estimate seizure-motion duration and autonomic responses. Results:The two novel classifiers consistently outperformed the previous detector. The most efficient (Classifier III) yielded sensitivity of 94.55%, and false alarm rate (FAR) of 0.2 events/day.No nocturnal seizures were missed. Most patients had less than 1 false alarm every 4 days with FAR below their seizure frequency. When increasing the sensitivity to 100% (no missed seizures) the FAR is up to 13 times lower than the previous detector. Furthermore, all detections occurred before the seizure ended, providing reasonable latency (median: 29.3 s, range: 14.8-151 s). Automatically estimated seizure durations were correlated with true durations, enabling reliable annotations. Finally, EDA measurements confirmed the presence of post-ictal autonomic dysfunction, exhibiting a significant rise in 73% of the convulsive seizures. Onorati et al. 3 Significance:The proposed multimodal wrist-worn convulsive seizure detectors provide seizure counts that are more accurate than previous automated detectors and typical patient self-reports, while maintaining a tolerable FAR for ambulatory monitoring. Furthermore, the multimodal system provides an objective description of motor behaviour and autonomic dysfunction, aimed at enriching seizure characterization, with potential utility for SUDEP warning.

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The aim of this paper is to report the interaction design process followed by an interdisciplinary team to develop an innovative ICT wearable device for affective video gaming. The process follows Norman and Draper's User Centered Design principles [1] including: functional development, laboratory test of the technology with human subjects, product design, prototype realization and experimentation with final users. The functioning of the device is based on the detection of physiological parameters, e.g., Blood Volume Pulse (BVP), Temperature (T), and Galvanic Skin Response (GSR), through electrodes placed on the forehead of the player. These signals are aimed at detecting the emotional state of the player by means of computational intelligence algorithms. This information can be used to modify the behavior of a videogame in order to maintain the player in the desired state of subjective enjoyment. Our goal was to develop a comfortable and easy to use device to avoid disturbs on the emotional state of the player.