BackgroundIt is a known fact that blood flow pattern and more specifically the pulsatile time variation of shear stress on the vascular wall play a key role in atherogenesis. The paper presents the conception, the building and the control of a new in vitro test bench that mimics the pulsatile flows behavior based on in vivo measurements.MethodsAn in vitro cardiovascular simulator is alimented with in vivo constraints upstream and provided with further post-processing analysis downstream in order to mimic the pulsatile in vivo blood flow quantities. This real-time controlled system is designed to perform real pulsatile in vivo blood flow signals to study endothelial cells’ behavior under near physiological environment. The system is based on an internal model controller and a proportional-integral controller that controls a linear motor with customized piston pump, two proportional-integral controllers that control the mean flow rate and temperature of the medium. This configuration enables to mimic any resulting blood flow rate patterns between 40 and 700 ml/min. In order to feed the system with reliable periodic flow quantities in vivo measurements were performed. Data from five patients (1 female, 4 males; ages 44–63) were filtered and post-processed using the Newtonian Womersley’s solution. These resulting flow signals were compared with 2D axisymmetric, numerical simulation using a Carreau non-Newtonian model to validate the approximation of a Newtonian behavior.ResultsThis in vitro test bench reproduces the measured flow rate time evolution and the complexity of in vivo hemodynamic signals within the accuracy of the relative error below 5%.ConclusionsThis post-processing method is compatible with any real complex in vivo signal and demonstrates the heterogeneity of pulsatile patterns in coronary arteries among of different patients. The comparison between analytical and numerical solution demonstrate the fair quality of the Newtonian Womersley’s approximation. Therefore, Womersley’s solution was used to calculate input flow rate for the in vitro test bench.
BackgroundSince hemodynamics plays a key role in the development and evolution of cardiovascular pathologies, physician’s decision must be based on proper monitoring of relevant physiological flow quantities.MethodsA numerical analysis of the error introduced by an intravascular Doppler guide wire on the peak velocity measurements has been carried out. The effect of probe misalignment (±10°) with respect to the vessel axis was investigated. Numerical simulations were performed on a realistic 3D geometry, reconstructed from coronary angiography images. Furthermore, instead of using Poiseuille or Womersley approximations, the unsteady pulsatile inlet boundary condition has been calculated from experimental peak-velocity measurements inside the vessel through a new approach based on an iterative Newton’s algorithm.ResultsThe results show that the presence of the guide modifies significantly both the maximum velocity and the peak position in the section plane; the difference is between 6 and 17% of the maximum measured velocity depending on the distance from the probe tip and the instantaneous vessel flow rate. Furthermore, a misalignment of the probe may lead to a wrong estimation of the peak velocity with an error up to 10% depending on the probe orientation angle.ConclusionsThe Doppler probe does affect the maximum velocity and its position during intravascular Doppler measurements. Moreover, the Doppler-probe-wire sampling volume at 5.2 and 10 mm far from the probe tip is not sufficient to prevent its influence on the measurement. This should be taken into account in clinical practice by physicians during intravascular Doppler quantification. The new numerical approach used in this work could potentially be helpful in future numerical simulations to set plausible inlet boundary conditions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12938-016-0234-6) contains supplementary material, which is available to authorized users.
Large Eddy Simulation (LES) is growing in importance to support the development, validation and tuning of efficient and reliable engineering models. Such models are essential for the wind energy industry to predict the performance of wind turbines, especially when rotor-wake interactions are involved. In this paper, we present high-fidelity numerical results obtained with a new aero-servo-elastic solver relying on LES and the actuator line method. Two sub-configurations of the Westermost Rough wind farm are investigated: an isolated wind turbine and a seven-turbine row. For validation purposes, field data are compared to time-averaged numerical results for the rotation speed, blade pitch angle, output power, and blade loads. A very good agreement between the results and field data is obtained for the isolated turbine. For the seven-turbine row, some discrepancies are observed. Those can primarily be explained by the inherent difficulty of translating both the actual wind conditions and the influence of the neighboring row into boundary conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.