Synthesis of 3-fluoro-2-hetarylindoles through addition of hetarenes to 3,3-difluoroindolium ions generated in situ by Zn(OTf) 2 -catalyzed oxazolidine ring opening is described. Indoles, pyrroles and alkyl-substituted furans can be used as hetaryl nucleophiles to afford a range of 3-fluoro-2-hetarylindole products 6 in 56-95 % yields. A diverse array of 3,3-difluorinated 2-hetarylindolines 7 can also be synthesized in
The synthesis of various 3‐fluoro‐2‐hetarylindoles through addition of indoles, pyrroles, or alkyl‐substituted furans to 3,3‐difluoroindolium ions generated in situ by zinc triflate‐catalyzed oxazolidine ring opening is described.
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