Purpose
The purpose of this study is to investigate the effect of ketorolac on biofilm formation of
Staphylococcus epidermidis
isolated from patients with post-cataract endophthalmitis.
Methods
Forty
S. epidermidis
strains isolated from postoperative endophthalmitis were used for this study. Biofilms were grown on microtitre plates for 24 h, dyed, and stained with crystal violet. The mean optical density (OD) and the OD ratio (ODr = OD of the treated biofilm/OD of the untreated biofilm) were used for quantification. The biofilms were incubated with 13 mM ketorolac and without ketorolac for controls.
Results
The biofilm ODs of the
S. epidermidis
isolates untreated and treated with ketorolac were significantly different (0.335 ± 0.06 versus 0.158 ± 0.03, respectively; mean ± SD;
P
< 0.001). Ketorolac reduced
S. epidermidis
biofilm formation by 47.6 %.
Conclusions
Ketorolac, at a concentration of 13 mM, significantly reduces the formation of biofilm by strains of
S. epidermidis
that caused endophthalmitis.
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