Indonesia has been struggling to response the COVID-19 since the first reported COVID-19 cases in Indonesia on 2 March 2020. It is about three months after intensively scary news of pandemic occurrence among neighbour countries. All efforts had been conducted to prevent and control the spread of disease, included how to implement effectively the message of using mask, social distancing, stay at home, frequently washing hands (health protocol for COVID-19) by local wisdom, in regards that Indonesia has more than 30 races and ethnicities and spread out in more than 3000 inhabited islands. People's behaviour, based on its local wisdom, are dominantly influence the people's response to the spread of COVID-19. In some provinces, the people's behaviour influences the spread of COVID-19 effectively. However, in some other provinces, it may not influence the increasing incidence of the disease. Thus, the significantly decreasing of the COVID-19 incidence is still under expectation in the near future. Many efforts had been conducted by the Government of Indonesia, from central command in the beginning to delegate autonomy of command to province and city or district. Understanding the geo-ecology and characteristics of population dynamic are important to describe the mechanism of the spread of COVID-19 for more focus in control interventions.