No abstract

The reactions between [PdCl 2 (tmbiimH 2 )]·H 2 O (1) {tmbiimH 2 = 2,2'-bis(4,5-dimethylimidazole)} and thiourea (tu), N-methylthiourea (mtu), N-phenylthiourea (ptu), N,N'-dimethylthiourea (dmtu) or N,N'-diphenylthiourea (dptu) in the 1:2 molar ratio resulted in the compounds [PdL 2 (tmbiimH 2 )]Cl 2 ·nH 2 O {L = tu (2), mtu (3), ptu (4), dmtu (5) and dptu (6)}, which were characterized by elemental analyses, infrared (IR), and 1 H NMR spectroscopies and conductivity measurements. The IR spectra of 1-6 were consistent with the presence of chelating tmbimH 2 ligand. All compounds and cisplatin were tested in vitro by MTT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3), lung adenocarcinoma (LP07) and mouse fibroblast (L929) cells. Relating the series of compounds to their biological activities we found compound 6 as the most promising of them.

No abstract

No abstract