Synthesis, Characterization and Cytotoxicity Evaluation of New Biimidazole Palladium(II) Complexes with Thioureas

Franchi, Silmar José Spinardi; Souza, Rodrigo Alves de; Mauro, Antônio Eduardo; Carlos, Iracilda Zeppone; Ribeiro, Letícia; Rocha, Fábio R.P.; Netto, Adelino Vieira de Godoy

doi:10.17344/acsi.2017.4112

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…A great history of transition metal complexes is associated with their effectiveness in the numerous diseases cure, [1][2][3] including the major application in the field of novel anticancer drug discovery. The interaction of coordination compounds with various biomolecules is facilitated due to varying oxidation states of central metal ion, which can eventually result in surprising pharmacological and exceptional curative properties.…”

Section: Introductionmentioning

confidence: 99%

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Karia¹,

Vekariya²,

Patidar³

et al. 2019

ACSi

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Ruthenium(III) complexes [Ru(bphtpy)(PPh 3)Cl 3 ] (bphfpy = diphenylfuranylpyridine derivatives) were synthesized and characterized by LCMS, IR spectroscopy, elemental analysis and magnetic measurements. All the complexes were screened for their antibacterial activity in terms of minimum inhibitory concentration against two Gram-positive and three Gram-negative bacterial species. DNA binding study by absorption titration and viscosity measurement shows that complexes bind in an intercalating mode, which is also confirmed by molecular docking. All the complexes were also screened for the DNA nuclease property of pUC19 plasmid DNA. The cytotoxicity study of the synthesized complexes was performed to elucidate the LC 50 values to find out the toxicity profile of the complexes.

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Section: Introductionmentioning

confidence: 99%

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Karia¹,

Vekariya²,

Patidar³

et al. 2019

ACSi

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“…16 Synthesis of [Re(CO) 3 the compounds. 19 The extent of inhibition is displayed as an IC 50 value, which is defined as the concentration required to inhibit cell growth to half. 20,21 Stock solutions of 10-100 mg/mL of test complexes (I-VI) were prepared in dimethyl sulfoxide (DMSO).…”

Section: General Methods For Synthesis Of Pyrazolo[15-a]pyrimidines Lmentioning

confidence: 99%

Synthesis, Characterization and Biological Application of Pyrazolo[1,5-a]pyrimidine Based Organometallic Re(I) Complexes

Varma¹,

Pandya²,

Vaidya³

et al. 2020

ACSi

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The neutral rhenium(I) complexes (I-VI) of type [ReCl(CO) 3 L n ] {where L 1 = 7-phenyl-5-(pyridin-2-yl)pyrazolo[1,5-a] pyrimidine, L 2 = 7-(4-bromophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimi-dine, L 3 = 7-(4-chlorophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine, L 4 = 7-(2-chlorophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine, L 5 = 7-(4-methoxyphenyl)-5-(pyridin-2-yl)pyrazolo [1,5-a]pyrimidine, L 6 = 5-(pyridin-2-yl)-7-(p-tolyl)pyrazolo[1,5-a]py-rimidine} were synthesized and characterized by 13 C-APT, 1 H-NMR, IR, electronic spectra, magnetic moment and conductance measurement. The anti-proliferative activity on HCT116 cells by MTT assay suggests potent cytotoxic nature of complexes, some complexes even have better activity than standard drug cisplatin, oxaliplatin, and carboplatin. The complexes were found to have better antimicrobial activity compare to pyrazolo pyrimidine ligands. The theoretical study of compounds-DNA interactions was examined by molecular docking as a supportive tool to the experimental data, which suggests the groove mode of binding. The values of docking energy for compounds-DNA interaction were found in the range of-230.31 to-288.34 kJ/mol. The intrinsic binding constant values of complexes (1.1-3.5 × 10 5 M-1) were found higher than the ligands (0.32-1.8 × 10 5 M-1).

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“…9,10 They are used as therapeutic agents for the treatment of different diseases. [11][12][13][14] The scientific research in this field has proven that the binding of a drug to a metal increases its activity. In some cases, the complex has an even more interesting activity than the parent compound.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure, Hirshfeld Surface Analysis and Biological Activities of trans-Dipyridinebis (3-Acetyl-2-Oxo-2H-Chromen-4-Olato)Cobalt(II)

Bejaoui¹,

Rohlíček²,

Eigner³

et al. 2019

ACSi

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The novel cobalt(II) complex, trans-dipyridinebis(3-acetyl-2-oxo-2H-chromen-4-olato)cobalt(II), was synthesized in ethanol. The coordination sphere of the cobalt cation was elucidated using single-crystal X-ray diffraction analysis and spectroscopic techniques (FT-IR, UV-Visible and fluorescence). Hirshfeld surface analysis indicates that hydrogen bond interactions, such as C-H•••O hydrogen bonding between the oxygen of lactone group and the pyridine appear as a primary interaction between the complex's molecules. The presence of π-π stacking was evident by the shape index and curvature. Analysis of 2D fingerprint plots confirm that intermolecular H•••H, C•••H and H•••O interactions are well dominated and are in complement to the Hirshfeld surface. The metal-ligand coordination strongly influences the fluorescence intensity (the fluorescence quenching) and the offset of the emission wavelength. The metal complex was monitored for antimicrobial activity using the disk diffusion method and showed significant activity compared to the coumarin ligand.

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Synthesis, Characterization and Cytotoxicity Evaluation of New Biimidazole Palladium(II) Complexes with Thioureas

Cited by 4 publications

References 37 publications

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Synthesis, Characterization and Biological Application of Pyrazolo[1,5-a]pyrimidine Based Organometallic Re(I) Complexes

Crystal Structure, Hirshfeld Surface Analysis and Biological Activities of trans-Dipyridinebis (3-Acetyl-2-Oxo-2H-Chromen-4-Olato)Cobalt(II)

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