We have demonstrated that BMI may have an influence on the CT of healthy persons. Individuals in both Group 3 and Group 4 have thinner choroids than the individuals in both Group 1 and Group 2.

Objective: We aimed to compare intraocular pressure (IOP) measurements via three different tonometers: the Goldmann applanation tonometer (GAT), the Tono-Pen ® XL (TPXL), and a non-contact airpuff tonometer (NCT).Methods: This was a cross-sectional study of 200 eyes from 200 patients. Right eyes of all patients were included in this study. IOP was measured via GAT, NCT, and TPXL by three physicians. Each physician used one of the tonometers. Measurements via the three devices were compared. Results: The mean IOP was 15.5±2.2 mmHg (range 10-22) with the GAT, 16.1±3.0 (range 9-25) with the TPXL, and 16.1±2.8 (range 10-26) with the NCT. Bland-Altman analysis showed that the mean difference between measurements from the NCT and the GAT was 0.6±2.3 mmHg. The mean difference between the TPXL and GAT measurements was 0.7±2.5 mmHg. The mean difference between the NCT and TPXL measurements was -0.02±3.0 mmHg. There was no significant difference between the groups according to a one-way analysis of variance (ANOVA) test. P-values were 0.998 for NCT-TPXL, 0.067 for NCT-GAT, and 0.059 for TPXL-GAT. Conclusion:The NCT and TPXL provide IOP measurements comparable to those of the gold standard GAT in normotensive eyes.

Purpose To evaluate the visual, refractive, and topographic outcomes after simultaneous topography-guided transepithelial photorefractive keratectomy (transepithelial TG-PRK) using the Amaris Excimer laser platform and accelerated corneal cross-linking (CXL) in eyes with keratoconus. Materials and Methods Patients with 2 years of follow-up were included in this retrospective case series. Manifest refraction (MR), uncorrected (UDVA) and corrected (CDVA) distance visual acuity, corneal topography, and pachymetry were evaluated at 1, 3, 6, 12, and 24 months after surgery. The root-mean-square of total higher-order aberrations (total HOA-RMS), coma (Coma-RMS), and spherical aberration (SA-RMS) were calculated for 4- and 6-mm diameters. Results Forty-six eyes of 46 patients were included in the study. Stromal ablation was ≤50 μ in all patients. MR was −3.78±3.26 preoperatively and −1.39±1.82 postoperatively. Significant improvements were seen in the UDVA and Coma-RMS values at 1 month, CDVA and total HOA-RMS values at 3 months, and SA-RMS values at 1 year compared to preoperative levels. UDVA values further improved after 2 years, compared to the 1-year values. No patient lost two or more lines and keratoconus progression was not observed in any patient. Conclusion Simultaneous transepithelial TG-PRK and accelerated CXL resulted in significant gains in CDVA without compromising CXL efficacy.

PurposeTo evaluate the outcomes of 5-year ranibizumab treatment in neovascular age-related macular degeneration (nAMD) in a single center and real life clinical setting.MethodsThe records of nAMD patients who were treated with ranibizumab between January 2010 and June 2011 were retrospectively reviewed. Patients who completed 5 years of follow-up were included. Main outcome measures were change in best-corrected visual acuity, central retinal thickness, and visit and injection numbers.ResultsForty-four eyes of 37 patients were included. Mean best-corrected visual acuity decreased from 0.82 ± 0.69 to 1.11 ± 0.65 logarithm of minimal angle of resolution after 5 years. Twenty-four eyes (54.5%) had visual acuity loss ≥3 lines, and 20 eyes (45.5%) had stable or improved vision (loss <3 lines, remained stable, or gained ≥1 line) at month 60. The mean total number of visits was 25.3 ± 5.8 (range, 14 to 42), and the mean total number of injections was 12.6 ± 6.4 (range, 3 to 26) at month 60.ConclusionsHalf of the ranibizumab-treated nAMD patients maintained their vision during the 5 years of follow-up. Visit and injection numbers were found to be lower than in prospective studies, reflecting a real world clinical practice.

The aim of this study was to evaluate the visual outcomes and complications of deep anterior lamellar keratoplasty (DALK) performed using the big-bubble technique in patients with keratoconus. Methods: In this case series, 57 eyes of 57 patients with moderate to advanced keratoconus underwent DALK. All of the participants were contact lens-intolerant or had an unacceptable contact lens fitting as a result of advanced keratoconus. DALK was performed using the big-bubble technique. Full thickness donor corneas devoid of Descemet's membrane were sutured to the recipient bed. Preoperative and postoperative best spectacle-corrected visual acuity (BSCVA), corneal topography, and intra-postoperative complications were evaluated. Results: The mean age of 40 male (70%) and 17 female (30%) patients who had an average follow-up of 48.84±18.12 months (range: 12-60 months) in this study was 28±11.3 years (range: 7-63 years) at the time of the DALK procedure. The mean BSCVA increased from 1.41±0.44 logMAR to 0.87±0.37 logMAR at the final follow-up (p<0.001). The mean preoperative value of flat (K1) and steep (K2) curvature power was 53.5±8.8 diopters (D) and 60.6 ± 8.5 D, respectively, while the postoperative mean K1 and K2 value was 42.8±1.2 D and 46.06±1.3 D. Microperforation was seen in 6 patients (10.5%) during the suturation as an intraoperative complication. Postoperatively, 8 patients (14%) underwent suture revision and 1 patient (0.2%) underwent amniotic membrane transplantation. Conclusion: DALK using the big-bubble technique appears to be a safe and effective procedure in patients with keratoconus.