In our ongoing study of fungal bioactive natural products,
12 previously
undescribed triquinane sesquiterpene glycosides, namely, antrodizonatins
A–L (1–12), and four known
compounds (13–16) have been obtained
from the fermentation of the basidiomycete Antrodiella zonata. The structures were established unambiguously via extensive spectroscopic
analysis and theoretical calculations of electronic circular dichroism
spectra. This is the first report of triquinane sesquiterpene glycosides.
Compounds 1, 5, and 12 displayed
antibacterial activity against Staphylococcus aureus with MIC50 values of 35, 34, and 69 μM, respectively.
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