Diseases of the cardiovascular system remain an important medical and social problem throughout the world, since the prevalence, features of the clinical course and outcomes lead to a significant decrease in the quality of life. The study of the geographic variability of varicose veins of the lower extremities (hereinafter – VLE) can expand the understanding of this problem. Objective. To assess the regional features of the incidence of VLE in Kazakhstan for 2009-2018. Material and methods. The material for the study was the data of the Ministry of Health of the Republic of Kazakhstan – annual form No. 12, concerning VLE (ICD 10 – I83) for 2009-2018. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method. Results and discussion. For 2009-2018 in the republic 158 151 cases of VLE were registered for the first time, of which 37 670 (23.8%) in men and 120 481 (76.2%) in women. The average annual incidence rate of VLE (both sexes) in the republic was 91.6±9.6 per 100,000 of the total population (95% CI=72.8-110.30/0000). The lowest incidence rates of VLE in the entire population were established in Aktobe region – 28.1±1.40/0000 (95% CI=25.4-30.80/0000). Very high incidence rates (both sexes) were detected in North Kazakhstan region (130.5±7.60/0000, 95% CI=115.6-145.40/0000) and in Astana city (163.0±11.00/0000, 95% CI=130.6-195.40/0000). Conclusions. The study showed a preliminary assessment of VLE incidence in the republic, identifying regions of low and high frequency, trends of VLE morbidity. In dynamics, morbidity rates tended to grow. With the equalization of the incidence rates of VLE, the average annual growth rate was Т=+12.5%. Keywords: varicose veins of the lower extremities, incidence, Kazakhstan.
Nonspecific ulcerative colitis is a chronic inflammatory bowel disease of an immune nature with frequent localization in the large intestine. A pattern is noted that in the northern and western continents they suffer more often than in Asia. To identify risk factors in a population, epidemiological studies must firstly assess the incidence of disease. Aim. To study the trends of nonspecific ulcerative colitis (NUC) incidence in Kazakhstan. Material and methods. The research material was compiled summary reporting form number 12 of the Ministries and the Health of the Republic of Kazakhstan on new cases of nonspecific ulcerative colitis (ICD-10 – K51), established for the first time. A retrospective study was used as the main method for studying the incidence of NUC. According to generally accepted methods of biomedical statistics, extensive, intensive and equalized indicators of the incidence of NUC were calculated. Results and discussion. For 2013-2018 14,079 new cases of NUC were registered in the republic, of which 15 were in children – 15.3%, teenagers – 4.8% and adults – 79.8%. The average annual incidence rate of NUC in the entire population of Kazakhstan was 13.5±2.10/0000 (95% CI=9.4-17.50/0000), and for population groups having been studied was: in children – 7.2±2.10/0000 (95%CI=3.8-12.00/0000), among teenagers – 18.7±5.00/0000 (95% CI=9.0-28.50/0000) and the adult population 15.4±1.90/0000 (95% CI=11.8-19.10/0000). The difference in morbidity between groups was statistically significant. Disease tended to decrease in all age groups: in the adult population (Т=−12.3%), children (Т=−43.7%) and in adolescents (T=-50.1%). Conclusion. According to the dynamics, NUC incidence in Kazakhstan has a decreased tendency due to the child and adolescent population. The results obtained are recommended to be taken into account by health authorities when making managerial decisions. Keywords: nonspecific ulcerative colitis, morbidity, trends, Kazakhstan.
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