Diabetic foot ulcers (DFU) are a vascular complication of diabetes mellitus (DM). It has been confirmed that irisin is closely related to DM. However, the effect of irisin on DFU is obscure and needs further study.
After HUVECs were treated with different concentrations’ irisin, normal glucose, high glucose (HG), HG plus irisin-high (H) or sh-Notch1, cell biological behaviors, LDH, and VEGFA were detected by cell function experiments. Apoptosis- and Notch pathway-related protein levels were evaluated by western blot.
Irisin has no cytotoxicity, and irisin-H elevated cell viability, inhibited apoptosis and LDH level in HG-induced HUVECs. Meanwhile, irisin-H restored HG-repressed migration and angiogenesis in HUVECs. Irisin-H inhibited apoptosis-related protein levels, promoted VEGFA and Notch pathway-related protein levels in HG-treated HUVECs. Additionally, sh-Notch1 reversed the protective effect of irisin-H in HG-treated HUVECs.
Irisin restores HG-induced cell injury and angiogenesis in HUVECs by activating Notch pathway via Notch1.
Abstract. In saliency based video coding, the salient parts of the each frame are encoded with higher quality than non salient areas to improve the signal to noise ratio and get higher compression ratio. In this paper, the background of the saliency based video perceptual coding technology is introduced first. Then the characteristics of motion, color and texture are extracted to form the saliency map. The quantization control in high efficiency video coding (HEVC) is incorporated with the visual saliency map to reduce the bit rate by adaptively changing the quantization parameter. Experimental results show that the proposed method can save the bit rate with improving the perceptual quality of regions-of-interest.
Three high-efficient green light iridium complexes were designed and prepared. Thermal stabilities, electrochemical properties, electroluminescence performances and substituents effects are presented and discussed in this study.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.