The Cu(MeCN) PF /DTBM-Segphos complex catalyzed the highly diastereo- and enantioselective 1,3-dipolar cycloaddition of azomethine ylides with benzo[b]thiophene sulfones with the usual regiochemistry to give single isomers of the exo-cycloadducts in good yields. In contrast, the AgOAc/ThioClickFerrophos complex catalyzed the reaction with atypical regiochemistry to give the endo-cycloadducts as major products with excellent enantioselectivities. Thus, the choice of chiral metal complex enabled the regio- and stereoselective synthesis of chiral fused sulfolanes.
The AgOAc/ThioClickFerrophos
complex catalyzed conjugate additions
and 1,3-dipolar cycloadditions of 3-methyl-4-nitro-5-styrylisoxazoles
with 1-pyrroline-5-carboxylates and glycine imino esters to give the
corresponding Michael adducts and cycloadducts, respectively, in good
yields with excellent diastereo- and enantioselectivities. These reactions
can provide pyrroline- or pyrrolidine-containing isoxazole hybrid
molecules that have potential biological and pharmaceutical activities.
The 1,3‐dipolar cycloaddition of glycine imino esters (azomethine ylide precursors) with 1‐propene‐1,3‐sultone proceeded smoothly by using copper phosphine complexes at room temperature to give the bicyclic sultone‐fused pyrrolidines as single regio‐ and stereoisomers in good yields. A preliminary asymmetric reaction with a chiral copper complex gave the fused sultone‐pyrrolidine with excellent enantioselectivity.
Particle deposition in a jet engine is a complex physical phenomenon that includes free-surface flow and phase changes. The moving particle simulation (MPS) method is extremely useful for numerical simulations, although it incurs high computational costs. In this study, we used the multiresolution MPS (MRMPS) method to simulate the deposition phenomenon of a liquid droplet to reduce the computational cost. When using the MRMPS method, we modified some conditions concerning the division of the computational particle. As a result, the spreading behavior and rim shape of a droplet impinging on a cold wall with solidification showed reasonable agreement with the experiment. In addition, this model has the advantage of reducing the computational time.
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