The taxonomicalJ characters of 208 strains of glutamic acid-producing bacteria and the bas cTlpositions of DNA solated from representative strains were studied.Then organisms are, in general, Gram-positive, non-sporulating, nonmotile, ellipsoidal spheros to short rods, pleomorphic and require biotin for growth and acc ~im~ date aerobically large amounts of L-glutamic acid.
Several derivatives of mitomycin were prepared from natural mitomycins and subjected to antibacterial tests. The structure-activity relationship was investigated for enzymatic activation, inhibition of DNA synthesis, and prophage induction. Substituents X, Y, and Z in mitomycins (1) are closely related to the rate of activation, which has a great effect on the biological activity. The aziridine group is responsible for inhibition of DNA synthesis and also for alkylating actions of mitomycins.
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