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Preeclampsia (Pe) is a pregnancy-specific syndrome that has severe implications on perinatal mortality and morbidity. excessive apoptosis of trophoblasts induced by hypoxia may be associated with the development of Pe, but the exact pathogenesis is unknown. Forkhead box o transcription factor 3a (FoXo3a) is activated under hypoxic conditions. Furthermore, hypoxia-inducible factor-1α (HiF-1α) is sensitive to variations in partial oxygen pressure. Thus, the aims of the present study were to investigate the expression levels of HiF-1α and FoXo3a in placental samples of early onset severe Pe, and their effect on trophoblastic apoptosis under hypoxic conditions. cobalt chloride was used to establish the hypoxic model. The present study examined the expression levels of HiF-1α and FoXo3a in the placental tissues and HTr8/SVneo cells under hypoxic conditions. it was found that HiF-1α and FoXo3a were highly expressed in placental tissues of patients with Pe and in HTr8/SVneo cells under hypoxic conditions. Furthermore, knockdown of FOXO3a using a specific small interfering rna (sirna) decreased apoptosis in HTr8/SVneo cells. Moreover, it was found that after knockdown of HiF-1α using sirna, FoXo3a expression and the apoptotic rate were reduced in HTr8/SVneo cells. Therefore, the present results indicated that the elevated expression of HiF-1α increased trophoblastic apoptosis by regulating FoXo3a, which may be involved in the pathogenesis of Pe.

Resveratrol increases endothelial NO production to improve endothelial dysfunction and lowers BP in hypertensive rats, which depends on calcium-eNOS activation.

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Tea, originating from China, is an important part of Chinese traditional culture. There are different qualities of and producing areas for tea on the market, therefore it is necessary to discriminate between teas in a fast and accurate way. In this study, a chemical sensor array based on nanozymes was developed to discriminate between different metal ions and teas. The indicators for the sensor array are three kinds of nanozymes mimicking laccase (Cu‐ATP, Cu‐ADP, Cu‐AMP). The as‐developed sensor array successfully discriminated 12 metal ions and the detection limit was as low as 0.01 μM. The as‐developed sensor array was also able to discriminate tea samples. Different kinds of tea samples appeared in different areas in the canonical score plot with different response patterns. Furthermore, in a blind experiment, we successfully discriminated 12 samples with a 100% accuracy. This sensor array integrates chemistry and food science together, realizing the simultaneous detection of several kinds of teas using a sensitive method. The as‐developed sensor array would have an application in the tea market and provide a fast and easy method to discriminate between teas.

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