Background:The role of ubiquitin-interacting motifs (UIMs) in the deubiquitinating enzyme USP37 is unknown. Results: Inactivation of the UIMs in USP37 resulted in lower isopeptidase activity toward ubiquitin chains. Conclusion: The UIMs in USP37 are required for the full catalytic activity of the enzyme. Significance: This study reveals a novel mechanism to increase the catalytic activity of deubiquitinating enzymes.
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