Polydimethylsiloxane (PDMS) is a widely used material for biomedical applications. In this work, a convenient method for the covalent modification of PDMS with carboxybetaine was developed and used to construct a biocompatible and antifouling coating. Following the preparation of a Si-H functionalized PDMS film by adjusting the mole ratio of the two components used in Sylgard 184 silicone elastomer networks, the allyl carboxybetaine (ACB) was grafted to the PDMS surface via a hydrosilylation reaction in the presence of a Karstedt's catalyst. ATR-FTIR and water contact angle measurements revealed that carboxybetaine was introduced to the PDMS surface successfully. The biocompatibilities of PDMS and carboxybetaine-modified PDMS (PDMS-CB) films were evaluated by cytotoxicity, hemocompatibility, and dynamic clotting time. The anti-fouling properties of PDMS-CB were evaluated by protein adsorption and bacterial adhesion measurements. The results showed that the carboxybetaine layer could enhance the biocompatibility of PDMS and reduce the adsorption of protein and adhesion of bacteria efficiently. modification of PDMS was characterized by ATR-FTIR and water contact angle (WCA). The biocompatibility, including cytotoxicity, hemocompatibility, and dynamic clotting time, and the surface properties of PDMS, such as protein adsorption and bacterial adhesion, were also investigated.
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