Preparation of anti-fouling silicone elastomers by covalent immobilization of carboxybetaine

Abstract

Polydimethylsiloxane (PDMS) is a widely used material for biomedical applications. In this work, a convenient method for the covalent modification of PDMS with carboxybetaine was developed and used to construct a biocompatible and antifouling coating. Following the preparation of a Si-H functionalized PDMS film by adjusting the mole ratio of the two components used in Sylgard 184 silicone elastomer networks, the allyl carboxybetaine (ACB) was grafted to the PDMS surface via a hydrosilylation reaction in the presence of a Karstedt's catalyst. ATR-FTIR and water contact angle measurements revealed that carboxybetaine was introduced to the PDMS surface successfully. The biocompatibilities of PDMS and carboxybetaine-modified PDMS (PDMS-CB) films were evaluated by cytotoxicity, hemocompatibility, and dynamic clotting time. The anti-fouling properties of PDMS-CB were evaluated by protein adsorption and bacterial adhesion measurements. The results showed that the carboxybetaine layer could enhance the biocompatibility of PDMS and reduce the adsorption of protein and adhesion of bacteria efficiently. modification of PDMS was characterized by ATR-FTIR and water contact angle (WCA). The biocompatibility, including cytotoxicity, hemocompatibility, and dynamic clotting time, and the surface properties of PDMS, such as protein adsorption and bacterial adhesion, were also investigated.

Fifty Years of Hydrosilylation in Polymer Science: A Review of Current Trends of Low-Cost Transition-Metal and Metal-Free Catalysts, Non-Thermally Triggered Hydrosilylation Reactions, and Industrial Applications

“…Zhang et al used allyl-carboxybetain as grafting reagent on elastomeric PDMS via a Karstedt-catalyzed hydrosilylation to increase the anti-fouling properties. Their protein/bacterial adhesion indicated improved biocompatibility and reduced adsorption and adhesion properties regarding proteins and bacteria [140]. For a systematic description of the influence of long hydrophobic side-chains on antimicrobial activity, the reader is referred to a recent research article on that topic [141].…”

Superhydrophobic Silicone/TiO2–SiO2 Nanorod‐like Composites for Marine Fouling Release Coatings

“…The average number of bacterial cells in 10 areas of the SEM images for each sample was counted (Figure a). The bacterial adhesion test revealed the excellent anti‐adhesive behavior of the modified silicone surface at a 0.5 wt.% nanofiller concentration, which is highly eligible for building AF surfaces …”

“…The bacterial adhesion test revealed the excellent anti-adhesive behavior of the modified silicone surface at a 0.5 wt.% nanofiller concentration, which is highly eligible for building AF surfaces. [44] This result indicates the nanocomposites' high resistance to the adhesion of bacterial cells through disintegration and selfcleaning. The low number of bacterial cells obtained at 0.5 wt.% concentrations were due to the excellent distribution of core-shell, photocalaytic self-cleaning properties, and absence of agglomerations at this level.…”

Optical Temperature Sensors Based On Europium(III) Beta‐Diketonate Complexes Chemically Bonded To Functionalized Polydimethylsiloxane

“…The siloxane bond present in PDMS increases the flexibility of the PDMS polymeric chain compared to organic polymers, which resulting in flexible mechanical properties. Also, polydimethylsiloxane can be easily functionalized by several methods, such as polycondensation, UV and peroxide radical induced reactions and hydrosilylation . Among these processes, the hydrosilylation is an interesting homogenous catalyzed reaction free of byproducts between a Si−H and vinyl groups, and several molecules containing different chemical groups can be attached to the PDMS polymeric chain, in order to improve solubility or to covalently bond the temperature luminescent probe.…”