FOLFIRINOX chemotherapy has shown remarkable responses in patients with metastatic pancreatic cancer (MPC), and has significantly improved prognosis. However, FOLFIRINOX is currently not frequently applied in China because of its high incidence of adverse events, and there is no recognized optimization for this therapy in Chinese population. Modification of FOLFIRINOX may be better for its acceptance in China. In this study, we evaluated the efficacy and safety of modified-FOLFIRINOX in patients with MPC. A total of 62 MPC patients were treated with modified-FOLFIRINOX (no Fluorouracil bolus, 85% Oxaliplatin and 75% Irinotecan) between April 2014 and April 2017 in our institute. 40 of them were evaluated, with a response rate of 32.5% (13/40). The frequent grade 3/4 adverse events are neutropenia (29%) and alanine aminotransferase elevation (14.5%). No treatment-related death was observed. The median overall survival and median progression-free survival are 10.3 months and 7.0 months, respectively. In conclusion, modified-FOLFIRINOX had significantly improved tolerance with similar efficacy to FOLFIRINOX. These findings may provide evidence for the use of FOLFIRINOX in Chinese patients with MPC.
The effects of lights with different wavelengths on the growth and the yield of extracellular polysaccharides of Nostoc flagelliforme cells were investigated in a liquid cultivation. N. flagelliforme cells were cultured for 16 days in 500 ml conical flasks containing BG11 culture medium under 27 micromol·m-2·s-1 of light intensity and 25 degrees C on a rotary shaker (140 rpm). The chlorophyll a, phycocyanin, allophycocyanin, and phycoerythrin contents in N. flagelliforme cells under the lights of different wavelengths were also measured. It was found that the cell biomass and the yield of polysaccharide changed with different wavelengths of light. The biomass and the yield of extracellular polysaccharides under the red or violet light were higher than those under other light colors. Chlorophyll a, phycocyanin, and allophycocyanin are the main pigments in N. flagelliforme cells. The results showed that N. flagelliforme, like other cyanobacteria, has the ability of adjusting the contents and relative ratio of its pigments with the light quality. As a conclusion, N. flagelliforme cells favor red and violet lights and perform the complementary chromatic adaptation ability to acclimate to the changes of the light quality in the environment.
A novel kind of hyamine-containing crosslinked β-cyclodextrin resin (β-CD-DEAE) was synthesized. 2-Diethylaminoethyl group (DEAE) was introduced on β-cyclodextrin by the reaction of 2-diethylaminoethyl chloride hydrochloride with β-cyclodextrin under basic condition and then the crosslinked resin was formed by the crosslink reaction using epichlorohydrin. The quaternary ammonium group was produced by the quaterisation of DEAE using epichlorohydrin. The new crosslinked cyclodextrin resin was characterized by scanning electron microscopy, Kjeldahl method and infrared spectroscopy. The content of nitrogen approaches approximately 5.55%. Meanwhile, the phenol adsorption property for wastewater treatment has been determined. It was found that the hyamine-containing crosslinked β-CD has a strong capability of phenol adsorption. Under the optimal pH of 9, the adsorbent dosage was 30mg/ml. If the initial phenol concentration was 100mg/l, the maximum phenol adsorption efficiency was 84.42%. In addition, the effective recycling efficiency of the new crosslinked β-CD resin was almost 100%.
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