2 AbstractPurpose of the study: Retinitis pigmentosa (RP) is a group of genetic disorders and a slow loss of vision is caused due to a cascade of retinal degenerative events. We examined whether these retinal degenerative events were relieved after the mixtures of cultured adult olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) were transplanted into the subretinal space of one month old RCS rat, a classic model of RP.

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Our findings indicate that therapeutic strategies aimed at rescuing cones in the degenerating retina should be applied before P21 and no later than P45 while substantial numbers of cones retain their ISs. Either the middle or peripheral regions of the nasal and superior retina are the best locations for transplantation strategies.