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The induction of systemic immunosuppression following ultraviolet B radiation exposure has been linked with the release of inflammatory and immunomodulatory mediators by cells of the epidermis and dermis. Nerve growth factor has not previously been linked with ultraviolet-B-induced immunosuppressive effects. Nerve growth factor antibodies abrogated ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in BALB/C mice. Subcutaneous injection of nerve growth factor (20 microg per mouse) into dorsal skin 5 d before hapten sensitization on ventral skin suppressed contact hypersensitivity responses in mast-cell-replete but not Wf/Wf mast-cell-depleted mice. Nerve growth factor injected 24 h prior to challenge was not able to suppress the efferent phase of the contact hypersensitivity response. Subcutaneous injection of nerve growth factor (20 microg per mouse) did not suppress contact hypersensitivity responses in capsaicin-pretreated (neuropeptide-depleted) BALB/c mice, and thus sensory c-fibers are necessary for nerve-growth-factor-mediated systemic suppression of contact hypersensitivity responses. Increased concentrations of nerve growth factor within epidermal keratinocytes 8 h after ultraviolet B irradiation were confirmed immunohistochemically. These findings support a role for keratinocyte-derived nerve growth factor via its action on sensory c-fibers, and subsequent release of neuropeptides to mediate mast cell degranulation in systemic suppression of contact hypersensitivity responses in mice following ultraviolet B exposure.

White-light emission in Lead halide hybrid perovskites has attracted increasing attention due to their significant applications in the field of light-emitting devices. Despite tremendous efforts, the two-dimensional (2D) white-light emissive...

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MeOMBrQ-Ho induced HeLa cell apoptosis was mediated by inhibition of telomerase activity and dysfunction of mitochondria. Remarkably, MeOMBrQ-Ho obviously inhibited HeLa xenograft tumor growth in vivo.

Compared with 1–9, 10–13 displayed stronger cytotoxic activities against the tested A549/DDP cells. 11 and 13 could induce apoptosis and autophagy in A549/DDP cells and exhibited pronounced and selective activity against A549/DDP xenografts in vivo.

A novel luminescent Zn(II)-based metal–organic framework with twofold interpenetrating [Zn(DHT)(BPP)]n (GUPT-2) {GUPT = Guangdong University of Petrochemical Technology, H2DHT = 2,5- dihydroxyterephthalic acid, and BPP = 1,3-di(4-pyridyl)propane} was successfully synthesized...

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