BackgroundThe objective of this study was to compare the efficacy, safety and tolerability of intravenous iron sucrose with that of oral ferrous fumarate in iron deficiency anemia during 14 to 34 weeks of pregnancy.MethodsA randomized controlled trial was performed involving 112 patients attending the antenatal clinic at Shri B.M.Patil Medical college Hospital, Bijapur from October 2011 to August 2012,with hemoglobin levels between 70-110 g/L and serum ferritin of < 15 ng/ml.In the intravenous group,200 mg of iron sucrose was administered in 100 ml 0.9% sodium chloride per day. Participants in the oral group were given 200 mg of ferrous fumarate per day. The primary outcome measures for the trial, haemoglobin and serum ferritin levels were measured after 4 weeks. Statistical significance was assessed using Student’s t-test.ResultsThe change in haemoglobin in women receiving intravenous iron was higher than with oral ferrous fumarate 22 ± 11.5 g/L vs 12 ± 9 g/L (p < 0.0001).Similarly the change of serum ferritin was significantly higher in women receiving intravenous iron compared to oral iron.55% participants in the intravenous group had an improvement in haemoglobin more than 20 g/L compared to only 11% of the oral therapy group.48% of patients in I.V group showed increase in ferritin level between 51 to 100 ng/ml in comparison to only 3.5% in oral group.Intravenous iron sucrose is an effective in correction of anemia in pregnancy or iron store depletion.ConclusionIntravenous iron sucrose is more effective than 200 mg a day ferrous fumarate in increasing maternal iron stores.Trial registrationThe trial registration number is CTRI/2016/12/007552 registered in Clinical Trial Registry India on 8/12/2016. It is a retrospectively registered trial.
Introduction Prevalence of malaria in pregnancy is 1.4%. A high index of suspicion is most important in the diagnosis of malaria and should be differentiated from other complications like eclampsia, intrauterine sepsis. Case Report Gravida 3 para 2 living 1 (G3P2L1) with 28 weeks gestation was referred with high blood pressure (BP), severe anemia. She was afebrile, severe pallor +, pedal edema +, pulse rate (PR)—110/ min, BP—140/80 mm Hg, per abdomen (P/A)— Ut 28 to 30 weeks size relaxed with fetal heart sounds (FHS) regular. Hemoglobin (HB) 5.3 gm%, platelet count 80,000. After 3 days, patient threw one convulsion. Low dose MgSO4 regime given. Peripheral smear (PS) for malarial parasite (MP) vivax positive and injection quinine 1200 mg in 10% dextrose started. She was induced and delivered. Discussion In pregnancy malaria is more common, more atypical, more severe and more fatal. Once diagnosed treatment should be started immediately and pregnant woman should be given full doses of antimalarials. Both eclampsia and malaria are to be treated. How to cite this article Jaju PB, Bhavi SB. Convulsions: Eclampsia or Malaria or Both! J South Asian Feder Obst Gynae 2015;7(3):245-246.
The objective of this study was to see the efficacy, safety and tolerability of intravenous iron sucrose in iron deficiency anemia during 14 to 34 weeks of pregnancy. A clinical trial was performed involving 56 patients attending the antenatal clinic at Shri B M Patil Medical College Hospital, Bijapur from October 2011 to August 2012, with hemoglobin levels between 70-110g/L and serum ferritin of < 15 ng/ml. Iron sucrose was administered as 200 mg in 100 ml 0.9% sodium chloride per day. The primary outcome measures for the trial, haemoglobin and serum ferritin levels were measured after 4 weeks. The change in haemoglobin in women receiving intravenous iron was higher 22 ±11.5 g/L (p<0.0001). Similarly the change of serum ferritin was significantly higher in women receiving intravenous iron. 55% of participants had an improvement in haemoglobin more than 20 g/L. 48% of patients showed increase in ferritin level between 51 to 100 ng/ml. Intravenous iron sucrose is more effective in correction of anemia and increasing maternal iron stores.
The objective of this study was to see the changes in the serum ferritin levels on administration of intravenous iron sucrose in iron deficiency anemia during 14 to 34 weeks of pregnancy. A clinical trial was performed involving 56 patients attending the antenatal clinic at Shri B M Patil Medical College Hospital, Bijapur from October 2011 to August 2012, with serum ferritin of < 15 ng/ml and hemoglobin levels between 70-110g/L. Iron sucrose was administered as 200 mg in 100 ml 0.9% sodium chloride per day. The primary outcome measures, serum ferritin and haemoglobin levels were measured after 4 weeks. The change in serum ferritin was 112.17 ± 98.15 ng / ml (Mean ±SD) which was significantly higher with T value 5.11 and P value being < 0.0001. 48% of patients showed increase in ferritin level between 51 to 100 ng/ml. Serum ferritin levels increase with intravenous iron sucrose administration thus making it effective in increasing maternal iron stores along with correction of anemia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.