Outcome of intravenous iron sucrose in treatment of anemia in pregnancy

Abstract

The objective of this study was to see the efficacy, safety and tolerability of intravenous iron sucrose in iron deficiency anemia during 14 to 34 weeks of pregnancy. A clinical trial was performed involving 56 patients attending the antenatal clinic at Shri B M Patil Medical College Hospital, Bijapur from October 2011 to August 2012, with hemoglobin levels between 70-110g/L and serum ferritin of < 15 ng/ml. Iron sucrose was administered as 200 mg in 100 ml 0.9% sodium chloride per day. The primary outcome measures for the trial, haemoglobin and serum ferritin levels were measured after 4 weeks. The change in haemoglobin in women receiving intravenous iron was higher 22 ±11.5 g/L (p<0.0001). Similarly the change of serum ferritin was significantly higher in women receiving intravenous iron. 55% of participants had an improvement in haemoglobin more than 20 g/L. 48% of patients showed increase in ferritin level between 51 to 100 ng/ml. Intravenous iron sucrose is more effective in correction of anemia and increasing maternal iron stores.