Background:Hypocalcemia is one of the most common acceptable complications in postoperative period after thyroidectomy. Hypomagnesemia has been recognized after parathyroid surgery, and it has not been studied extensively after thyroidectomy. The aim of this study was to estimate magnesium and calcium ion levels in patients undergoing thyroidectomy and to evaluate the association of hypomagnesemia with hypocalcemia after thyroidectomy. A prospective study was conducted in Government Medical College, Calicut, from December 2012 to November 2013.Materials and Methods:all patients had undergone total/near-total/subtotal thyroidectomy. Pre- and postoperative at 24 h and serum calcium and magnesium were measured by automate electrolyte analyzer. Clinical findings of hypocalcemia were recorded. Statistical analysis was done using SPSS software, version 17.0. Unpaired student t-test was used. Pearson Chi-square test or Fisher's exact test was used to compare the percentage for categorical variables.Results:In our study, 58% of the patients developed hypocalcemia, biochemical and/or symptomatic (S. Ca <8.5). About 34% of patients developed hypomagnesemia, biochemical and/or symptomatic (S. Mg <1.7). About 30% of patients developed both hypocalcemia and hypomagnesemia. About 24% of patients developed symptoms of both hypocalcemia and hypomagnesemia.Discussion:Thyroidectomy patients were at a risk of transient and permanent hypoparathyroidism because of chances of parathyroid resection during operation. Transient hypocalcemia and hypomagnesemia occur frequently after total thyroidectomy. It is important to monitor both calcium and magnesium levels after total thyroidectomy and to correct deficiencies to facilitate prompt resolution of symptoms.Conclusion:There is an association of hypomagnesemia with hypocalcemia after thyroidectomy.
The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease. Thyroid disorders often accompany abnormal serum enzyme levels and disturbances in liver functions. These thyroid-liver associations may cause diagnostic confusions. Neglect of these facts may result in over or under diagnosis of associated liver or thyroid diseases and thereby cause errors in patient care. Aim of the present study was to determine the biochemical markers of liver function test Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP) in patients with hypothyroidism and to find their possible correlation with thyroid profile. Material and Methods: The study included 50 patients with subclinical hypothyroidism (TSH 6.0-9.9miu/l), 50 patients with overt hypothyroidism (TSH ≥10.0 miu/l) and 50 age matched normal euthyroid controls. In all study groups FT3, FT4, TSH, AST ALT and ALP were estimated. Thyroid profile and LFT were estimated using fully autoanalyser. p value <0.05 considered as significant. Results: Subjects with both subclinical hypothyroidism and overt hypothyroidism had significantly raised serum AST, ALT and ALP (p<0.0001) compared to controls. Further, TSH showed significant positive correlation with AST, ALT and ALP (P<0.001) in both subclinical and overt hypothyroidism, Conclusion: Hypothyroid patients should be regularly checked for biochemical parameters of LFT. As early detection and treatment can prevent the further complications related to the disorder and will be helpful during the management of hypothyroid patients.
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