BACKGROUND: Alcohol Dependence syndrome (ADS) is one of the most common psychiatric disorders that has deleterious consequences not only on the patient with ADS but also hampers social, financial, and legal matters of his family hence could be considered as a disorder of the family. Spouses of patients with ADS, a key member of such dysfunctional family system, are most vulnerable to have significant psychiatric disorders like adjustment disorders, mood disorders, anxiety disorders and psychosocial problems. Hence we have undertaken this study in order to understand and address such issues which is largely neglected in psychiatric research. AIMS AND OBJECTIVES: To assess the severity of alcohol dependence & its adverse effect on families, the prevalence and pattern of psychiatric morbidity and marital quality in spouses of men with ADS and to explore the association between them. MATERIALS AND METHODS: 60 spouses of males with ADS according to Diagnostic and Statistical Manual of Mental Disorders-IV (DSM IV-TR) Criteria were screened for psychiatric morbidity using General Health Questionnaire and the presence of specific psychiatric disorders using Structured Clinical Interview for DSM-IV AXIS-I & AXIS-II (SCID-I & SCID-II). Severity of alcohol dependence in males and its adverse consequences was assessed using Short Alcohol Dependence Data and Drinkers Inventory of Consequences, respectively. Marital quality was assessed using the marital quality scale. Data obtained was analyzed statistically. RESULTS: High prevalence of Psychiatric morbidity (63.33%) among spouses of alcohol dependent men, with majority having Axis I diagnosis of Major Depression (35%), Anxiety and Adjustment Disorder. None of them had personality disorders on SCID II. Psychiatric morbidity, poor marital quality in spouses and high alcohol dependence in their husbands and its adverse consequences were found to be significantly correlated with each other and their association was robust particularly Impulse Control, Interpersonal and Social Responsibility were most affected. CONCLUSION: Spouses of alcohol dependent men have high Psychiatric morbidity and low Marital Quality. Addressing these issues will be beneficial as spouses are known to play an important role in the treatment of ADS.

To estimate prevalence of psychiatric co-morbidity and its effect on quality of life in persons with Hansen's disease. METHOD: The study was conducted on around 80 persons above 18 year age with Hansen's disease in outpatient department dermatology and in leprosy home. Participants were diagnosed cases of Hansen's disease, selected randomly and were evaluated with socio demographic questionnaire, Duke's general health questionnaire, DSM-5 self rated level 1 cross cutting symptom measure-adult and WHO-QOL-BREF. The period of data collection was from October 2014 to March 2015. RESULTS: The assessment showed that prevalence of at least one psychiatric co morbidity was 83.75% (67/80 patients) and of these 67 patients 18(26.86%) have one diagnosis, 26(38.80%) have two diagnoses and 23(34.32%) have 3 or more psychiatric diagnoses. Among all depression was most prevalent (28.35%) mental disorder; followed by anxiety disorder (23.88%). Quality of life was significantly impaired in almost all persons with Hansen's disease. CONCLUSION: Persons with Hansen's disease have significantly high prevalence of mental disorders which have much impact on their quality of life which were under diagnosed and thus remained untreated.

BACKGROUND: Psoriasis is relatively common, chronic inflammatory and hyperproliferative skin disease that affects 1.4% to 2.0% of the population. Presence of itching, chronic recurrent course of disease and incomplete cure may contribute to great deal of psychiatric comorbidity in these patients. the most persuasive indications of a link between stress and psoriasis comes from patients themselves, with studies illustrating that the majority of patients believe that stress or psychological distress is a factor in the manifestations of their condition. Depression and anxiety are the most common disorders that are associated with psoriasis, but the proportion of patient also having other psychiatric co-morbid diseases which include social phobia, generalize anxiety disorder, panic disorder, psychotic disorder, etc. Moreover, symptoms of psoriasis, especially pruritus, are related to depression. OBJECTIVES: To evaluate different psychiatric illnesses their prevalence and severity in psoriasis patients. METHODOLOGY: This was crosssectional observational study comprised of 70 consecutive patients of psoriasis attending the outpatient department of Dermatology. All the patients were subjected to detailed examinations including the elicitation of dermatological and psychiatric profile after getting written consent for study. Data was collected using self-developed, pre tested, semi structured Pro format by interview method. RESULTS: The profile of psychiatric diagnoses obtained in the present study depressive disorder 31.4% {18.57% depression, 12.85% Depression with anxiety symptoms}, anxiety disorder 25.7% (7.14% GAD, 8.17% panic disorder, 5.71% social phobia, 4.28 specific phobia). Severity of major depressive disorder was determined with HAM-D score 53.8% had mild depression, 30.7% moderate depression and 15.5% severe depression. Similarly when HAM-A scale was used to determined severity of generalized anxiety disorder in psoriasis patients then 40% had mild anxiety 40% had moderate anxiety and 20% had severe anxiety. CONCLUSION: Psoriasis is associated with high level of psychiatric co-morbidity. Depression and anxiety disorders were most frequent disorders present co-morbidly in patients of psoriasis. There was no co-relation between severity of psoriasis and psychiatric illness.

Introduction: Schizophrenia is a chronic debilitating disease having a major impact on the sufferers’ lives. Antipsychotic drugs are the mainstay of the treatment of schizophrenia. But, antipsychotics can lead to a variety of sexual dysfunctions among the males with schizophrenia, which may affect their treatment compliance. Aim: To assess the prevalence and the types of sexual dysfunctions among married males with remitted schizophrenia who were on a single oral antipsychotic drug from either class (i.e., typical or atypical type). Materials and Methods: The present cross-sectional study was conducted in a tertiary health-care centre from Central India, with a sample size of 100 married males with schizophrenia who were in the remission phase on a single oral antipsychotic drug. Data were collected by using a convenient sampling method. Socio-demographic profile and clinical variables were recorded in a specific case report form prepared for the study using the Arizona Sexual Experiences (ASEX) scale and the Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale to assess the prevalence and the types of oral antipsychotic drugs induced sexual dysfunctions among study participants. Results: The prevalence of antipsychotic drug induced sexual dysfunction was 54%. The most common type of sexual side-effect of oral antipsychotic treatment was Decreased Sexual Desire/Drive (DSD) as assessed by both ASEX (94.4%) and UKU (63.0%) scales. Sexual dysfunctions like DSD and Ejaculatory Dysfunction (EJD) were associated with the treatment of schizophrenia with typical antipsychotic drugs. Conclusion: The present study shows that the treatment with typical antipsychotics was significantly associated with sexual side-effects. So, routine inquiry during the follow-ups should be done regarding the evaluation of sexual side-effects of antipsychotic agents in order to improve treatment compliance and disease prognosis.

BACKGROUND: Non-compliance or non-adherence to treatment is the degree to which a patient does not carry out the clinical recommendation of a treating physician or in other words it is failure of the patient to follow the prescribed treatment regimen. Mental illnesses are treatable and need medication and other therapies i.e. counseling, psychotherapy etc. for the better outcome. Poor compliance to psychiatric medication regimens is a major obstacle to the effective care of persons who have chronic mental illness. OBJECTIVES: The study aims to identify the level of compliance and factors associated with non-compliance to treatment regimen in schizophrenic patients. METHODS: This was a hospital based cross sectional study carried out in psychiatric ward and OPD. A total of 52 patients were included as study samples. Data was collected using self-developed, pre tested, semi structured Pro format by interview method. RESULTS: Majority (69%) of the patients showed poor compliance. 27% of patients had Medium compliance and only 4% showed high compliance rate. Possible contributory factors responsible for noncompliance include cost of medicine, chronic nature of illness perceived, transportation problem, medication related factors like side effects of drug and lack of effectiveness, (relatives' insight toward illness), lack of knowledge, misconception about psychiatric disorders and patient's insight towards illness. CONCLUSION: The present study concluded that there are many factors which (Contribute) to non-compliance among patients with psychotic illness. (The findings of the study highlighted the various factors such as drug related, social support, and treatment access related factors are influencing the drug compliance among the schizophrenic patients).

Since the outbreak of the COVID-19 pandemic, increasing evidence suggests that infected patients present a high incidence of thrombotic complications. Besides affecting respiratory tract it also causes systemic inflammation which also leads to coagulopathy affecting major blood vessels in the body. This report describes a case of aortic, renal artery thrombosis in a patient admitted for evaluation of abdominal pain and detected to have high titer of SARS COV-2 IgG antibodies with no prior history suggestive of typical COVID-19 infection (COVID-19 RTPCR and antigen tested negative).

Toxic psychosis in adults although it is relatively uncommon side-effect in proportion to the large worldwide consumption of the drugs, there has been a number of case reports of Fluoroquinolone-associated psychosis. Our study was first of its kind as no other prospective cohort study on the use of fluoroquinolones and its relation to development of psychosis has yet been carried out. 2007 patients who were prescribed fluoroquinolones were followed for one month for development of any signs of psychosis out of which 22 patients that is 1.11% was found to have fluoroquinolones induced psychosis. We also discuss the possible neurophysiological mechanisms behind fluoroquinolones induced psychosis.

Today, population is moving with modernization in the 21th centaury a lot of new diseases emerge out; many are life style disorders out of them Asthma is the most common chronic lower respiratory disease in adults and childhood throughout the world and Ayurved addresses it as Tamakshwasa . Respiration is the evident feature of life which is carried out by Prana vayu. This sole sign of life is affected in the disease Tamakshwasa, causing in the impediment to the respiratory function. Tamakashwasa is correlated with Bronchial Ashtama on the basis of its feature and etiopathogenesis. As Prevalence of Asthma is increasing steadily over the lateral part of the last century, first in the developed and developing world. This Article Represent the review study on the emergency management of Tamakshawasa (Bronchial Asthma ) through ayurved with supporting evidences from studies conducted which includes combination of shaman chikitsa and life style management.