The purpose of this study was to measure the recovery kinetics of pH and lactate for the conditions of pre-exercise acidosis, alkalosis, and placebo states. Twelve trained male cyclists completed 3 exercise trials (110% workload at VO2max), ingesting either 0.3 g/kg of NH4Cl (ACD), 0.2 g/kg of Na+HCO3- and 0.2 g/kg of sodium citrate (ALK), or a placebo (calcium carbonate) (PLAC). Blood samples (heated dorsal hand vein) were drawn before, during, and after exercise. Exercise-induced acidosis was more severe in the ACD and PLAC trials (7.15 +/- 0.06, 7.21 +/- 0.07, 7.16 +/- 0.06, P < 0.05, for ACD, ALK, PLAC, respectively). Recovery kinetics for blood pH and lactate, as assessed by the monoexponential slope constant, were not different between trials (0.057 +/- 0.01, 0.050 +/- 0.01, 0.080 +/- 0.02, for ACD, ALK, PLAC, respectively). Complete recovery of blood pH from metabolic acidosis can take longer than 45 min. Such a recovery profile is nonlinear, with 50% recovery occurring in approximately 12 min. Complete recovery of blood lactate can take longer than 60 min, with 50% recovery occurring in approximately 30 min. Induced alkalosis decreases metabolic acidosis and improves pH recovery compared to acidodic and placebo conditions. Although blood pH and lactate are highly correlated during recovery from acidosis, they recover at significantly different rates.
In this study we investigated the compressive quasi-static mechanical properties and dynamic impact behavior of baseballs. Our purpose was to determine if static testing could be used to describe dynamic ball impact properties, and to compare static and dynamic properties between traditional and modified baseballs. Average stiffness and energy loss from 19 ball models were calculated from quasi-static compression data. Dynamic impact variables were determined from force–time profiles of balls impacted into a flat stationary target at velocities from 13.4 to 40.2 m/s. Peak force increased linearly with increasing ball model stiffness. Impulse of impact increased linearly with ball mass. Coefficient of restitution (COR) decreased with increasing velocity in all balls tested, although the rate of decrease varied among the different ball models. Neither quasi-static energy loss nor hysteresis was useful in predicting dynamic energy loss (COR2). The results between traditional and modified balls varied widely in both static and dynamic tests, which is related to the large differences in mass and stiffness between the two groups. These results indicate that static parameters can be useful in predicting some dynamic impact variables, potentially reducing the complexity of testing. However, some variables, such as ball COR, could not be predicted with the static tests performed in this study.
A diffuse reflectance near-infrared (NIR) spectrometer was evaluated as a noninvasive alternative to breath and blood measurements for in vivo alcohol testing. A hybrid partial least squares (PLS) calibration was constructed using a combination of in vivo and in vitro spectral data. This model was subsequently evaluated for its performance in quantifying alcohol concentrations in vivo using a prospective validation study involving subjects who did not participate in the calibration. The validation study entailed induction of alcohol excursions in ten human subjects and comparison of the noninvasive NIR alcohol measurements to blood and breath alcohol measurements. Blood and breath alcohol measurements were performed at the time of each noninvasive NIR measurement (N = 372), establishing the noninvasive NIR measurement standard error relative to blood alcohol at 4.9 mg/dL (0.0049%). Assessment of the hybrid calibration model's sensitivity and selectivity provided strong evidence that the hybrid calibration yielded measurements that were both sensitive to alcohol and independent of other absorbing analytes in human tissue.
Although not common, injuries that result in death do occur in youth baseball. Specifically, in the 5- to 14-year old age group a total of 68 deaths between 1973 and 1995 have been directly attributed to impacts from baseballs to the head and chest. The purpose of this work was to determine the effect of lowering ball modulus and ball mass on the likelihood of reducing impact injury. A theoretical model, based upon the assumption of ideal elastic behavior, was used to calculate the impact response of the head. At a constant ball velocity, lowering both modulus and mass had the greatest influence in decreasing peak head acceleration, Gadd Severity Index, and Head Injury Criterion. Independently lowering the modulus or the mass decreased the impact variables and the estimates of injury, but the decreases varied with the specific impact variable and injury criterion. To study the impact response of the ball and chest, an existing viscoelastic lumped-element model of the chest was used. Lowering ball modulus and mass had various effects, e.g., lowering ball modulus did not affect peak sternal displacement, but it did decrease peak sternal velocity. These theoretical models aid in illustrating that impact response depends upon ball modulus and mass, the physical properties of the target, and the specific impact variable studied. This theoretical model suggests that a softer and lighter than traditional baseball would be the most likely ball model to minimize impact injuries because this ball consistently reduced all impact response variables studied. Since impact injury criteria for youths are presently not validated, the degree to which impact injuries may be reduced remains uncertain.
Mechanisms by which weak electromagnetic fields may affect biological systems are of current interest because of their potential health effects. Lednev has proposed an ion parametric resonance hypothesis (Lednev, 1991, Bioelectromagnetics, 12:71-75), which predicts that when the ac, frequency of a combined dc-ac magnetic field equals the cyclotron frequency of calcium, the affinity of calcium for calcium-binding proteins such as calmodulin will be markedly affected. The present study evaluated Lednev's theory using two independent systems, each sensitive to changes in the affinity of calcium for calmodulin. One of the systems used was the calcium/calmodulin-dependent activation of myosin light chain kinase, a system similar to that previously used by Lednev. The other system monitored optical changes in the binding of a fluorescent peptide to the calcium/calmodulin complex. Each system was exposed to a 20.9 microT static field superimposed on a 20.9 microT sinusoidal field over a narrow frequency range centered at 16 Hz, the cyclotron frequency of the unhydrated calcium ion. In contrast to Lednev's predictions, no significant effect of combined dc-ac magnetic fields on calcium/calmodulin interactions was indicated in either experimental system.
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