Six groups of albino rats were used (6 rats in each group). Group M received Mebo ointment, Group Creceived Cica silver spray, Group K received Vitamin K injection, Group MK received Mebo ointment+vitamin K injection.Group CK received Cica silver spray +vitamin K Group, and Group N received no-treatment. The duration of the experiments was as 7, 14, and 21 days post wound surgery.The percentage of wound contraction was measured, and the blood serum was collected to test the level of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF). Results: Data presented in our study showed that the best wound contraction percentage (99%) was obtained by the MK treated rats compared to the control group. Similar results were obtained fromTGFβ and PDGF data in which MK group showed a significant increase in the levels of these growth factors. Conclusion:The wound healing process is supposed to be due to an increase of TGFβ, PDGF, and enhanced fibroblast proliferation and neovascularization of tissues.
The potential therapeutic properties of indigenous plants have been studied worldwide and were used either for treatment or prevention of various diseases. Punicagranatum (pomegranate), a plant from family Lythraceae, has been reported to enclose many medical properties like chemopreventive, 1 antioxidant, 2 antifungal, 3 anti-inflammatory, 4 antibacterial, 5 and wound healing. 6 It also has been reported to have a preventive role against obesity. 7 Phytochemical screening of Punicagranatum extract found to contain steroids, triterpenoids, saponins, glycosides, flavonoids, alkaloids, carbohydrate tannins, and vitamin C. 8 The red color of juice can be pointed to anthocyanins such as cyanidin, delphinidin and pelargonidin glycosides. 9,10 The peel contains three times more polyphenols compared to the pulp such as catechins, condensed t a n n i n s 1 1 g a l l o c a t e c h i n s a n d prodelphinidins. 12 This study aimed to study the antibacterial and anti-ulcerogenic activities of Punicagranatum peel extract on ethanol induced gastric lesions on experimental rats.Background and objectives: Punicagranatum (pomegranate) is a fruit-bearing deciduous shrub or small tree from the family Lythraceae. It has been cultivated since ancient times throughout the Mediterranean region. Different parts of it have been used for research, such as fruits, peels, and juice. This study aimed to investigate the antibacterial and anti-ulcer effect of Punicagranatum peel extract and to screen the expression of transforming growth factor β1 (TGF β1) in rat's blood serum after stomach ulcer was induced by ethanol. Methods: Twenty four rats were divided randomly into 4 groups; GroupI(ulcer positive group) rats were (experimental) orally administered 5 ml/kg sterilized distilled water (the vehicle). Group II (ulcer negative group) rats were orally administered 5 ml/kg of 20 mg/kg esomeprazole. Groups III and groups IV were orally administered 5 ml/kg of 250 and 500 mg/kg of Punicagranatum plant extract, respectively. Results: Data showed an antibacterial activity of Punicagranatum peel extract against gram positive and gram negative bacteria and the best antibiotic in which both bacteria were sensitive to was norfloxacin(10 µg). Treatment with Punicagranatum peel extract and esomeprazole had protective effects on stomach gastric mucosa, which indicate an anti-ulcer effect confirmed by the high levels of TGFβ1 in serum. Conclusion:We conclude that Punicagranatum peel extract exhibit antibacterial effect and possess a protective role against ethanol induced gastric ulcer in rats.
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