No abstract

No abstract

For Abstract see ChemInform Abstract in Full Text.

The methanolic extract of the root wood of Michelia compressa (Maxim.) Sargent showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Bioassay-guided fractionation of the chloroform-soluble layer led to the isolation of costunolide and liriodenine with cytotoxic activities, along with the isolation of twenty-seven known compounds. The active costunolide existed as major constituent in this study.

No abstract

Investigation of the root extract of Antidesma pentandrum var. barbatum led to the isolation of seven new compounds, antidesmol (1), antidesmanins E (2) and F (3), antidesnone (4), antidesnol (5), barbatumols A (6) and B (7), together with 14 known compounds including sodium aristolochate‐I (10) and aristolochic acid‐I methyl ester (11).

Four new coumarinolignans, antidesmanin A (=7‐(1,1‐dimethylallyl)‐2,3‐dihydro‐3‐(4‐hydroxy‐3,5‐dimethoxyphenyl)‐10‐methoxy‐2‐methyl‐6H‐1,4,5‐trioxaphenanthren‐6‐one; 1), antidesmanin B (=3,7‐bis(1,1‐dimethylallyl)‐2,3‐dihydro‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐10‐methoxy‐6H‐1,4,5‐trioxaphenanthren‐6‐one; 2), antidesmanin C (=2,7‐bis‐(1,1‐dimethylallyl)‐2,3‐dihydro‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐10‐methoxy‐6H‐1,4,5‐trioxaphenanthren‐6‐one; 3) and antidesmanin D (=2‐(3,4‐dihydroxyphenyl)‐3,7‐bis(1,1‐dimethylallyl)‐2,3‐dihydroxy‐10‐methoxy‐6H‐1,4,5‐trioxaphenanthren‐6‐one or 3‐(3,4‐dihydroxyphenyl)‐2,7‐bis(1,1‐dimethylallyl)‐2,3‐dihydro‐10‐methoxy‐6H‐1,4,5‐trioxaphenanthren‐6‐one; 4) have been isolated from the root of the Formosan Antidesma pentandrum var. barbatum. The structures of these new compounds were elucidated by spectroscopic data. Compounds 1–3 exhibited marginal cytotoxicity against MCF‐7 (breast) and SF‐268 (CNS) cancer cell lines in vitro.

No abstract