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Cited by 20 publications
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References 32 publications
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“…However, the problem has been minimized by the use of 4-hydroxy coumarin along with warfarin to maintain therapy and to inhibit the tumor spread [9]. In case of leukemia, prostate and breast cancer, cyclin D1 is released in an amount more than a normal levels and coumarin derivatives have also been found very effective antiproliferative agents by regulating the release of cyclin D1 [10-19]. …”
Section: Introductionmentioning
confidence: 99%
“…However, the problem has been minimized by the use of 4-hydroxy coumarin along with warfarin to maintain therapy and to inhibit the tumor spread [9]. In case of leukemia, prostate and breast cancer, cyclin D1 is released in an amount more than a normal levels and coumarin derivatives have also been found very effective antiproliferative agents by regulating the release of cyclin D1 [10-19]. …”
Section: Introductionmentioning
confidence: 99%
“…23) were synthesized. Among them, coumarin-4-yl α-methylene-γ-butyrolactone 77(R= H) with IC 50 values ≤14.68 µM showed the highest antiproliferative activity against MCF7, NCI-H460, and SF-268 cell lines[131]. ones) are an important class of natural products that showed versatile pharmacological effects including anticancer activity[132].…”
mentioning
confidence: 99%
“…[1][2][3] The useful medical properties associated with these naturally occurring coumarins have lead to the investigation of several synthetic analogues. A large number of compounds containing coumarin have been investigated because of their anti-inflammatory 4 , antibacterial 5 , vasorelaxant 6 , antihepatitis-C virus agent 7 and antiproliferative activities 8 . In view of this, and as continuation of our effort [9][10][11][12][13][14][15] to identify new, potent, selective and less toxic antimicrobial agents, we aimed to synthesise a new coumarin derivative that exhibits high therapeutic activity.…”
mentioning
confidence: 99%