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Furylf uramide(2-(2-f uryl)-3-(5-nitro-2-furyl) acrylamide) is a chemical which had been used widely in such foods as soybean caud, fish paste product and fish sausage as a food preservative in Japan from 1965 to 1974. The effects of furylfuramide on pregnant mice, fetuses and neonates were studies in ICR: JCL mice for three generations. Furylf uramide at dietary concentations of 0.1 or 0.5% was fed to both male and female weanling mice (F0). Thereafter the same dietary concentrations were administered continuously to each generation until F2 offspring were 60 days of age. Hepatic enlargement and degenerative hepatic changes were consistently found in the treated dams and their offspring. High mortality in F1 neonates and poor conception in F1 dams occurred in the group fed 0.5% furylf uramide. Suppression of body weight gain was also observed in pregnant mice and offspring at the 0.5% level. However, continuous administration of f urylf uramide for three generations did not increase fetal mortality nor did it cause major malformations.

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Sodium nitrite (NaNO2) was administered to pregnant mice during the critical period (from 6th the day to the 15th day of gestation) of the organogenesis in fetuses to examine the teratogenic effects of the food additive (color fixative) NaNO2. The dosages of NaNO2 employed in this experiment were 20, 40, 80 and 120mg/kg/day. On the 17th day of gestation, fetuses were removed by Caesarean section in order to examine their body weights, external malformations and skeletal. The results obtained can be summarized as follows; 1) Significant suppression of the body weight of pregnant mice was observed in the 80-and 120mg/ kg/day exposed-groups. 2) In the group of pregnant mice exposed to 120mg/kg, the numbers of implantations and living fetuses, along with the litter size, were significantly decresed as compared with those of the control group. 3) Cleft palate was observed sporadically in the exposed NaNO2 groups. However, the incidence was not significant as compared with the frequency observed in the control group. 4) Fetuses with a 14th rib were observed in exposed groups. However, this was considered to be within the spontaneous incidence of ICR mice. 5) Suppression of body weight gain was observed in the offspring of the group exposed to 120mg/kg/ day for the first 14 days. However, retardation was recovered from at 7 weeks of age.

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