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A survey study for Vibrio cholerae in imported seafood was conducted during January 1991 to December 1994. A total of 7,439 specimens (approximately 20% of all imported food) were randomly picked up and examined for contamination of V. cholerae. Among these, V. cholerae O1 were isolated from 9 specimens, but they were all cholerae enterotoxin (CT)-negative. In terms of V. cholerae non-O1, a total of 2,803 specimens (37.4%) were contaminated with this vibrio. Shrimp, especially the ones still in their shells and imported from Asian countries such as India and Indonesia, were highly contaminated with V. cholerae. Although no strains of V. cholerae O1 isolated in this study produced CT, 2 strains of V. cholerae non-O1 were proved to be CT-producers. Taking together the high contamination of V. cholerae in imported seafood and a part of those strains producing CT, we believe that careful survey for the possible contamination of V. choleare in imported seafood is necessary.

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In the quality test of 2 brands of film coated tablets containing 20mg of metoprolol tartrate, their dissolution, weight variation, content uniformity, disintegration and hardness were studied. Their weight variation was 0.8 to 1.9%, content 20.1 to 20.4mg, and disintegration time less than 10.8 min, all meeting the JP X requirements.The hardness was 5.7 to 6.3 kg/ cm2. In the dissolution test with use of the 1st fluid (Disintegration Test, JP X) by rotatory basket method, 50 and 90% dissolution times (T50 and T90) of the 2 brands were almost the same, while the results obtained by the paddle method were not so different from those by rotatory basket method. In addition, the effect of pH on Tiso and Too was studied. Too and To of 2 brands were influenced slightly by pH of dissolution fluid. No other significant differences were observed between 2 brands.