Introduction The root cause of preeclampsia is placental ischemia due to impaired trophoblastic invasion in the uterine spiral arterioles. Ischemic placenta liberates various inflammatory mediators that cause widespread endothelial dysfunction leading to insulin resistance (IR). Increased IR in pregnant females can further lead to high occurrence of maternal and fetal complications. Objectives To compare and evaluate the role of measuring IR among women with preeclampsia and normal pregnancy. Materials and methods A total of 35 women with preeclampsia and 35 women with normal pregnancy were included in the study as cases and controls, respectively. Fasting plasma glucose (FPG) and fasting plasma insulin (FI) were measured and IR indices, such as FPG to FI ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), and log FI were calculated. Unpaired Student's t-test was used for comparison. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 17.0. Results The mean FI and log FI were significantly higher while QUICKI and FGIR were significantly lower in cases when compared with controls (p < 0.001). Conclusion As disease advances, IR increases. There is increased risk of maternal and fetal complications in presence of increased IR. Screening of all hypertensive pregnancies for IR and timely intervention may help to improve outcome. How to cite this article Sonagra AD, Deba Z, Makandar A, Biradar SM. Study of Insulin Resistance in Women with Preeclampsia. Indian J Med Biochem 2017;21(2):127-130.
Background: Gestational hypertension (BP ≥ 140/90 mm of Hg without proteinuria) is classified under hypertensive disorders of pregnancy (HDP). HDP causes widespread endothelial dysfunction leading to hypertension and damage to vital organs such as liver, kidney, brain etc. Damage to kidney may lead to elevation in urinary excretion of albumin which can be used for predicting severity of the disease. Aims & Objective: This study was done to detect presence of microalbuminuria and to evaluate role of its estimation among women with gestational hypertension and normal pregnancy. Material and Methods: Case control study was done taking 40 women with gestational hypertension as cases and 40 age matched healthy pregnant women as controls. Urinary concentration of albumin was measured using immunoturbidimetry kit. Statistical analysis was done using SPSS 17.0. Results: Urinary excretion of albumin was significantly increased in women with gestational hypertension compared with controls. Its level significantly positively correlated with systolic and diastolic blood pressure. Conclusion: Urinary albumin excretion gradually increases as the disease severity increases. Early & regular monitoring for microalbuminuria in women with gestational hypertension may give a clue of disease severity and associated organ damage.
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